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MS_Thesis_RohanSinha_Final.pdf (3.49 MB)

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Bandwidth-Optimized Acoustic Transducer Array for At-Home Vascular Access Stenosis Detection

Sinha, Rohan Kumar
http://rave.ohiolink.edu/etdc/view?acc_num=case1654092149954224

Abstract Details

2022, Master of Sciences (Engineering), Case Western Reserve University, EECS - Electrical Engineering.
Over one million people worldwide rely on a vascular access to receive life-sustaining hemodialysis, yet early detection of vascular access stenosis is often limited to physical inspection and auscultation of the access by a practitioner, caregiver, or the patient themself. While convenient, auscultation is subjective and limited by the narrow bandwidth of stethoscopes which may not fully capture the high-frequency sounds of turbulent flow induced by stenosis. Because the auscultation procedure relies on expert detection of certain acoustic signatures, this suggests a wider bandwidth, objective monitoring methodology could enable automated, at-home monitoring. This work begins by determining a minimum critical bandwidth from bruits recorded at physiologic flow rates and degrees of stenosis. This bandwidth informed the design of frontend transimpedance amplifiers which interfaced with a 2-d array of custom fabricated piezoelectric sensors. A flexible printed circuit board was designed to house the sensors and front-end amplifiers while conforming to uneven surfaces for close mechanical coupling. The assembled devices were characterized in the time and frequency domains and tested in vitro on a vascular phantom to demonstrate stenosis detection performance. Recordings were analyzed with bruit-enhancing and pulse segmentation filters to derive the auditory spectral flux and auditory spectral centroid in each phase of blood flow at each microphone. Spectral features were derived and analyzed by magnitude and location-differential to demonstrate the array’s ability to detect stenosis location and severity.
Christian Zorman, PhD (Committee Chair)
Allison Hess-Dunning, PhD (Committee Member)
Evren Gurkan-Cavusoglu, PhD (Committee Member)
Steve Majerus, PhD (Committee Member)
92 p.
Biomedical Engineering; Biomedical Research; Electrical Engineering

Recommended Citations

Citations

  • Sinha, R. K. (2022). Bandwidth-Optimized Acoustic Transducer Array for At-Home Vascular Access Stenosis Detection [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1654092149954224

    APA Style (7th edition)

  • Sinha, Rohan. Bandwidth-Optimized Acoustic Transducer Array for At-Home Vascular Access Stenosis Detection. 2022. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1654092149954224.

    MLA Style (8th edition)

  • Sinha, Rohan. "Bandwidth-Optimized Acoustic Transducer Array for At-Home Vascular Access Stenosis Detection." Master's thesis, Case Western Reserve University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=case1654092149954224

    Chicago Manual of Style (17th edition)

case1654092149954224
77
© 2022, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.