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THE PAPER 11.9.17.pdf (1.47 MB)

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THE RELATIONSHIP BETWEEN VITAMIN D, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND RISK FOR FALLS ON INDIVIDUALS WITH MULTIPLE SCLEROSIS

Landean, Megan N
http://orcid.org/0000-0001-5428-0712
http://rave.ohiolink.edu/etdc/view?acc_num=csu1511794427717765

Abstract Details

2017, Master of Education, Cleveland State University, College of Education and Human Services.
Purpose: This study aimed to determine whether Vitamin D and BDNF levels are related to risk of falling in individuals with multiple sclerosis. Methods: Eighteen individuals with MS underwent a series of cognitive and physical tests. These tests included the BICAMS, Berg-Balance Test (BBT), Timed Get-Up and Go (TUG), Physiological Profile Assessment (PPA), and the timed 25-foot walk (25TFW). 25(OH)D and BDNF levels were assessed by ELISA following a blood draw. Results: The average 25(OH)D level was 44.3568ng/ml (± 26.88912ng/ml) and the average BDNF level was 37,180.0200pg/ml (± 12438.84345pg/ml). The fall risk assessment (PPA) had a mean total score was 2.16 (± 1.75). The correlation analysis didn't show any relationship between the primary outcomes. However, there was a trend showing lower vitamin D concentrations in fallers v. non-fallers. There was also a trend in reaction time, anterior-posterior sway, and proprioception and the concentration of BDNF. Conclusion: Lower vitamin D was linked to higher risk for falls while BDNF levels were found to play a possible role in anterior-posterior sway, proprioception, and reaction time.
Douglas Wajda, Ph.D. (Committee Chair)
Kenneth Sparks, Ph.D. (Committee Member)
Emily Kullman, Ph.D. (Committee Member)
Anatomy and Physiology; Biochemistry; Biomedical Research; Neurology; Neurosciences; Occupational Therapy; Pathology; Physical Therapy
Multiple Sclerosis; Vitamin D; BDNF; mobility; falls; fall risk; cognition

Recommended Citations

Citations

  • Landean, M. N. (2017). THE RELATIONSHIP BETWEEN VITAMIN D, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND RISK FOR FALLS ON INDIVIDUALS WITH MULTIPLE SCLEROSIS [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1511794427717765

    APA Style (7th edition)

  • Landean, Megan. THE RELATIONSHIP BETWEEN VITAMIN D, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND RISK FOR FALLS ON INDIVIDUALS WITH MULTIPLE SCLEROSIS. 2017. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1511794427717765.

    MLA Style (8th edition)

  • Landean, Megan. "THE RELATIONSHIP BETWEEN VITAMIN D, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND RISK FOR FALLS ON INDIVIDUALS WITH MULTIPLE SCLEROSIS." Master's thesis, Cleveland State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=csu1511794427717765

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Cleveland State University and OhioLINK.