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Dissertation - Nikkhil Velingkaar.pdf (1.49 MB)

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TEMPORAL FASTING AND REDUCED CALORIES INDEPENDENTLY CONTRIBUTE TO METABOLIC BENEFITS OF CALORIC RESTRICTION

Velingkaar, Nikkhil
http://orcid.org/0000-0003-1571-0833
http://rave.ohiolink.edu/etdc/view?acc_num=csu1568132919804719

Abstract Details

2019, Doctor of Philosophy in Regulatory Biology, Cleveland State University, College of Sciences and Health Professions.
Caloric restriction (CR) intervention has been demonstrated to improve health and extend lifespan. CR in mammals, imposes a short interval of feeding, called time restricted feeding (TR), which is followed by prolonged interval of fasting. TR or mealtime (MT), a form of periodic fasting, without reducing caloric intake, may contribute to improvement in metabolism. To dissect the contributions of reduced caloric intake and periodic fasting in health benefits mediated by CR, we measured physiological and metabolic parameters in mice subjected to CR and TR (without reduction in caloric intake). CR reduced blood glucose and insulin, and increased ketone levels across the day, significantly improved glucose and insulin sensitivity. TR did not affect blood glucose and glucose sensitivity, in contrast to CR, but reduced blood insulin and partially improved insulin sensitivity. Both the diets had little to no effect on phases of circadian clock genes, and CR significantly induced the expression of glucose metabolic genes, whereas TR did not, which correlates with modest effect of TR on glucose homeostasis. Therefore, we concluded that, TR is metabolically different from CR, and that periodic fasting contributed to some of the metabolic improvements on CR, independent from caloric intake. This may help provide a mechanistic explanation to differences in lifespan extension observed under CR and TR.
Roman Kondratov (Advisor)
Crystal Weyman (Committee Member)
Barsanjit Mazumder (Committee Member)
Girish Shukla (Committee Member)
Olga Stenina-Adognravi (Committee Member)
Anton Komar (Other)
Yana Sandlers (Other)
125 p.
Biology
aging; metabolism; glucose homeostasis; circadian rhythms; gene expression; insulin sensitivity; caloric restriction; fasting; circadian clock; longevity; feeding behavior

Recommended Citations

Citations

  • Velingkaar, N. (2019). TEMPORAL FASTING AND REDUCED CALORIES INDEPENDENTLY CONTRIBUTE TO METABOLIC BENEFITS OF CALORIC RESTRICTION [Doctoral dissertation, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1568132919804719

    APA Style (7th edition)

  • Velingkaar, Nikkhil. TEMPORAL FASTING AND REDUCED CALORIES INDEPENDENTLY CONTRIBUTE TO METABOLIC BENEFITS OF CALORIC RESTRICTION. 2019. Cleveland State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1568132919804719.

    MLA Style (8th edition)

  • Velingkaar, Nikkhil. "TEMPORAL FASTING AND REDUCED CALORIES INDEPENDENTLY CONTRIBUTE TO METABOLIC BENEFITS OF CALORIC RESTRICTION." Doctoral dissertation, Cleveland State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1568132919804719

    Chicago Manual of Style (17th edition)

csu1568132919804719
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© 2019, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.