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Stowie Dissertation (edited).pdf (1.52 MB)

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COCAINE MODULATION OF CIRCADIAN TIMING: A PUTATIVE MECHANSIM FOR DRUG DEPENDENCE

Stowie, Adam Curtis
http://orcid.org/0000-0002-7007-9135
http://rave.ohiolink.edu/etdc/view?acc_num=kent1427974849

Abstract Details

2015, PHD, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
While the circadian system regulates many physiological and behavioral aspects of cocaine abuse, to date little is known about what, if any, impact cocaine use has on circadian function. The present work is the first to characterize both acute and chronic cocaine effects on core circadian parameters such as free-running period, length of daily activity, phase angle of entrainment, and photic/non-photic phase resetting. Specifically, acute cocaine was found to phase-advance activity rhythms when administered at midday while interfering with photic phase-resetting prior to a light pulse during the early subjective night. Chronic cocaine had no effect on phase-angle of entrainment, length of daily activity, or activity rhythms under a light-dark regimen, but under constant darkness the free-running period was significantly lengthened, even following the withdrawal of cocaine access. Additionally, the mechanism by which cocaine acts on the daily timing system was investigated. Acute cocaine effects were abolished by the serotonin receptor antagonist metergoline, and mutant knock-in mice insensitive to the serotonergic effects of cocaine do not show either acute or chronic circadian disruption in response to cocaine. The present work is the first to indicate that cocaine acts directly on the circadian system and to show that this disruption is likely mediated via serotonergic signaling, indicating a possible regulatory loop whereby cocaine abuse disrupts circadian functioning affecting cocaine abuse behavior.
J. David Glass (Advisor)
Colleen Novak-Barnett (Committee Member)
Heather Caldwell (Committee Member)
Aaron Jasnow (Committee Member)
Douglas Delehanty (Committee Member)
87 p.
Neurobiology; Neurosciences; Physiology
Circadian; cocaine; mice; serotonin

Recommended Citations

Citations

  • Stowie, A. C. (2015). COCAINE MODULATION OF CIRCADIAN TIMING: A PUTATIVE MECHANSIM FOR DRUG DEPENDENCE [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1427974849

    APA Style (7th edition)

  • Stowie, Adam. COCAINE MODULATION OF CIRCADIAN TIMING: A PUTATIVE MECHANSIM FOR DRUG DEPENDENCE . 2015. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1427974849.

    MLA Style (8th edition)

  • Stowie, Adam. "COCAINE MODULATION OF CIRCADIAN TIMING: A PUTATIVE MECHANSIM FOR DRUG DEPENDENCE ." Doctoral dissertation, Kent State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1427974849

    Chicago Manual of Style (17th edition)

kent1427974849
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© 2015, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.