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Relationship between serum and brain luteinizing hormone and markers of neuroplasticity during the mouse estrous cycle

Sracic, Katya M
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors149427370693748

Abstract Details

2017, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Luteinizing hormone (LH) plays an important role in learning and memory. Previously, our laboratory has demonstrated that there is an inverse relationship between blood and brain levels of LH and that when levels are normalized post-ovariectomy, both cognition and spine density losses are reversed. Because these differences appear to depend on the reproductive status of the mouse, we determined whether normal cyclic fluctuations in LH during the estrous cycle correlate with neuronal markers of neuroplasticity that are associated with cognition. To address this, we measured serum LH levels using sandwich RIA ELISAs and determined changes in synaptophysin and spinophilin in the cingulate cortex, a cognition-associated brain region. As expected, both serum and cingulate cortex LH fluctuates throughout the estrous cycle. Furthermore, synaptophysin, but not spinophilin, correlated with LH levels in the cingulate cortex and serum. These changes show that LH may be involved in learning and memory, however further testing is necessary to clarify and confirm these results.
Gemma Casadesus, PhD (Advisor)
Aaron Jasnow, PhD (Committee Member)
Colleen Novak, PhD (Committee Member)
Alexander Seed, PhD (Committee Member)
44 p.
Biology; Biomedical Research; Neurosciences
luteinizing hormone; neuroplasticity; learning and memory; mouse estrous cycle; cingulate cortex; spinophilin; synaptophysin

Recommended Citations

Citations

  • Sracic, K. M. (2017). Relationship between serum and brain luteinizing hormone and markers of neuroplasticity during the mouse estrous cycle [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors149427370693748

    APA Style (7th edition)

  • Sracic, Katya. Relationship between serum and brain luteinizing hormone and markers of neuroplasticity during the mouse estrous cycle. 2017. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors149427370693748.

    MLA Style (8th edition)

  • Sracic, Katya. "Relationship between serum and brain luteinizing hormone and markers of neuroplasticity during the mouse estrous cycle." Undergraduate thesis, Kent State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors149427370693748

    Chicago Manual of Style (17th edition)

ksuhonors149427370693748
363
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This open access ETD is published by Kent State University Honors College and OhioLINK.