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The Effect of Estrogen on Microglial Inflammation in Surgically Ovariectomized Monkeys

Mafi, Amir M
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1512992487055556

Abstract Details

2017, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Menopause is a natural aging process in women which affects some metabolic and physiological states by reducing the gonadal steroid hormonal levels. In some cases, menopausal women can be prone to more serious health risks such as osteoporosis, cardiovascular diseases, and neurocognitive impairments such as Alzheimer’s disease due to loss of estrogen. Cognitive changes in response to hormone replacement therapy or in the absence of it have been widely studied on animal models. In this study, tissue from ovariectomized and estrogen replacement therapy treated post-menopausal monkeys were used to analyze brain inflammatory response by quantifying morphologically distinct microglial cells in the hippocampus. Specifically, we hypothesized that loss of circulating estrogen in the ovariectomized group would lead to a high number of activated microglial cells, while in the estrogen replacement therapy group, this number would be smaller indicating a lower inflammatory response. We did not find significant differences in the hippocampal volume among the three groups. Additionally, the total number or density of microglia did not differ significantly among the treatment groups, although there was a non-significant trend for microglia density to be lower in both ovariectomized and estrogen replacement therapy treated groups, as opposed to Intact controls.
Gregory Tinkler (Advisor)
John Johnson (Committee Member)
Alexander Seed (Committee Member)
Bansidhar Datta (Committee Member)
32 p.
Biology; Medicine; Neurobiology; Neurosciences

Recommended Citations

Citations

  • Mafi, A. M. (2017). The Effect of Estrogen on Microglial Inflammation in Surgically Ovariectomized Monkeys [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1512992487055556

    APA Style (7th edition)

  • Mafi, Amir. The Effect of Estrogen on Microglial Inflammation in Surgically Ovariectomized Monkeys. 2017. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1512992487055556.

    MLA Style (8th edition)

  • Mafi, Amir. "The Effect of Estrogen on Microglial Inflammation in Surgically Ovariectomized Monkeys." Undergraduate thesis, Kent State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1512992487055556

    Chicago Manual of Style (17th edition)

ksuhonors1512992487055556
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© 2017, all rights reserved.
This open access ETD is published by Kent State University Honors College and OhioLINK.
Release 3.2.12