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Treating Neuroinflammation with the Novel Hormone Irisin

Bretland, Kimberly
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1588335342425119

Abstract Details

2020, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
The exercise-induced hormone irisin shows therapeutic promise for reducing the damaging impact of metabolic conditions such as diabetes and cardiovascular disease, which are major midlife risk factors for developing Alzheimer’s disease (AD). Therefore, this project explored the potential for irisin to be used as a therapeutic in AD. We tested whether 1 month of weekly injections of recombinant human irisin would reduce neuroinflammation and tau pathology (i.e. tau hyperphosphorylation) in a transgenic mouse model (htau mice) that develops damaging tauopathy in the brain similar to what is seen in Alzheimer’s patients. Intraperitoneal injections of either 100 ug/mg of irisin or saline vehicle control were delivered to female and male htau mice and C57BL6J mice, a non-transgenic background-relevant strain we used as controls. After the 1-month treatment period, mice were sacrificed for brain tissue and blood collection. We used capillary-based Western blotting to measure tumor necrosis factor α (TNFα) as a surrogate indicator of inflammation in brain (hippocampus) and serum as well as hyper-phosphorylated tau (ptau) expression in hippocampus. Our results showed that irisin-treated female htau mice had significantly decreased TNFα and ptau in the hippocampus, along with a reduction of serum TNFα. Irisin-treated male htau did not show this therapeutic effect, and in fact, TNFα was significantly increased in these mice. These data support irisin’s potential as a therapeutic in AD-associated tau pathology and neuroinflammation. Further investigation needs to be done to fully understand the sex difference in this therapeutic effect and the precise mechanism by which irisin protects against these AD-related brain changes.
Christine Dengler-Crish (Advisor)
34 p.
Biology; Immunology; Neurosciences

Recommended Citations

Citations

  • Bretland, K. (2020). Treating Neuroinflammation with the Novel Hormone Irisin [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1588335342425119

    APA Style (7th edition)

  • Bretland, Kimberly. Treating Neuroinflammation with the Novel Hormone Irisin. 2020. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1588335342425119.

    MLA Style (8th edition)

  • Bretland, Kimberly. "Treating Neuroinflammation with the Novel Hormone Irisin." Undergraduate thesis, Kent State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1588335342425119

    Chicago Manual of Style (17th edition)

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© 2020, some rights reserved.Creative Commons License Treating Neuroinflammation with the Novel Hormone Irisin by Kimberly Bretland is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Kent State University Honors College and OhioLINK.