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Inflammatory Response and Oxidative Stress in Rats Selected for Intrinsic Aerobic Endurance Capacity

Maskiny, Charbel Farid
http://rave.ohiolink.edu/etdc/view?acc_num=mco1180467082

Abstract Details

2007, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Graduate Studies.
Innate inflammatory response is complex and involves biochemical processes leading to the activation of immune cells and subsequent production of a plethora of inflammatory mediators such as reactive oxygen species (ROS). To test the links between aerobic capacity, inflammation, ROS, and inflammatory diseases rat lines of Low Capacity Runners (LCR) and High Capacity Runners (HCR) were used. Substantial data suggests that these lines have separated for disease-related phenotypes such as blood pressure and insulin resistance. Because of the widespread association of inflammation with many diseases, we tested the hypothesis that LCR and HCR differ in their acute inflammatory response. The LCR and HCR were challenged with carrageenan, a pro-inflammatory polysaccharide. LCR accumulated 3.2 fold more exudate compared to HCR (p≤0.0001). These results could not be explained at the level of macrophages oxidative burst. The differential innate immune response between HCR and LCR is a disease-related phenotype, which requires further work to be more understood.
Douglas Pittman (Committee Chair)
Lauren Koch (Other)
Steven Britton (Other)
Sonia Najjar (Other)
Bina Joe (Other)
60 p.
Biology, Molecular
aerobic capacity; oxidative stress; innate immune response; animal model of health and disease

Recommended Citations

Citations

  • Maskiny, C. F. (2007). Inflammatory Response and Oxidative Stress in Rats Selected for Intrinsic Aerobic Endurance Capacity [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1180467082

    APA Style (7th edition)

  • Maskiny, Charbel. Inflammatory Response and Oxidative Stress in Rats Selected for Intrinsic Aerobic Endurance Capacity. 2007. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1180467082.

    MLA Style (8th edition)

  • Maskiny, Charbel. "Inflammatory Response and Oxidative Stress in Rats Selected for Intrinsic Aerobic Endurance Capacity." Master's thesis, University of Toledo, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1180467082

    Chicago Manual of Style (17th edition)

mco1180467082
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© 2007, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.