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mco1217365784.pdf (1.8 MB)
ETD Abstract Container
Abstract Header
Characterization of Genomic MidRange Inhomogeneity
Author Info
Bechtel, Jason M.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784
Abstract Details
Year and Degree
2008, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Graduate Studies.
Abstract
Genomes encode many signals at multiple levels. They must therefore manifestinhomogeneity in their nucleotide composition. Inhomogeneity is identifiable from the shortrange where neighboring nucleotides influence the choice of base at a site, to the longrange, commonly known as isochores, where a particular base composition can span millions of nucleotides. This work explores the mostly overlooked phenomenon of genomic midrange inhomogeneity (MRI). MRI is defined as an interdependence between nucleotide choice and base composition over a distance of 301000 base pairs. Through the investigation of thousands of human genes, the results presented herein establish the existence of MRI throughout mammalian genomes, establish a link with strong local secondary structures and characterize the properties of MRI. A public computational resource has been created to support further study of genomic MRI.
Committee
Alexei Fedorov, PhD (Committee Chair)
Robert Trumbly, PhD (Committee Member)
Robert Blumenthal, PhD (Committee Member)
Neocles Leontis, PhD (Committee Member)
Pages
103 p.
Subject Headings
Bioinformatics
;
Biostatistics
;
Genetics
Keywords
inhomogeneity
;
cluster
;
CpG island
;
genomic MRI
;
RNA secondary structures
;
mid-range
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Citations
Bechtel, J. M. (2008).
Characterization of Genomic MidRange Inhomogeneity
[Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784
APA Style (7th edition)
Bechtel, Jason.
Characterization of Genomic MidRange Inhomogeneity.
2008. University of Toledo, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784.
MLA Style (8th edition)
Bechtel, Jason. "Characterization of Genomic MidRange Inhomogeneity." Master's thesis, University of Toledo, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1217365784
Chicago Manual of Style (17th edition)
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Document number:
mco1217365784
Download Count:
654
Copyright Info
© 2008, some rights reserved.
Characterization of Genomic MidRange Inhomogeneity by Jason M. Bechtel is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.
Release 3.2.12