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Formulation, Characterization and Evaluation of Paclitaxel loaded Solid Lipid Nanoparticles Prepared by Temperature Modulated Solidification Technique.

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2015, Master of Science (MS), University of Toledo, Pharmaceutical Sciences (Industrial Pharmacy).
The aim of this research was to formulate, characterize, and evaluate the paclitaxel loaded solid lipid nanoparticles (SLNs) prepared by a temperature modulated solidification technique developed and optimized in our laboratory. The particle size analysis through dynamic light scattering (DLS) and transmission electron microscopy (TEM) revealed and confirmed the spherical shape and nanometer size range of the formulated nanoparticles. Zeta potential measurements confirmed the physical stability of the SLNs with a negative surface charge. Atomic force microscopy (AFM) studies were done to study the surface topography and particle size and shape. AFM data showed minimal aggregation and more or less spherical SLNs. Differential scanning calorimetry (DSC), powder X-ray diffraction (P-XRD) and Fourier transform infrared spectroscopy (ATR-FTIR) confirmed the conversion of bulk lipid into SLNs and high entrapment of paclitaxel into the lipid matrix. The optimized formulation had an entrapment efficiency of approximately 62%. The in-vitro drug release depicted a sustained release of paclitaxel from the SLNs over duration of one week. The drug release data was found to best fit and hence followed the Higuchi drug-release model.
Jerry Nesamony (Committee Chair)
Sai Hanuman Sagar Boddu (Committee Member)
Caren Steinmiller (Committee Member)
106 p.

Recommended Citations

Citations

  • Deshpande, A. A. (2015). Formulation, Characterization and Evaluation of Paclitaxel loaded Solid Lipid Nanoparticles Prepared by Temperature Modulated Solidification Technique. [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1436557604

    APA Style (7th edition)

  • Deshpande, Ameya. Formulation, Characterization and Evaluation of Paclitaxel loaded Solid Lipid Nanoparticles Prepared by Temperature Modulated Solidification Technique. 2015. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1436557604.

    MLA Style (8th edition)

  • Deshpande, Ameya. "Formulation, Characterization and Evaluation of Paclitaxel loaded Solid Lipid Nanoparticles Prepared by Temperature Modulated Solidification Technique." Master's thesis, University of Toledo, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1436557604

    Chicago Manual of Style (17th edition)