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Ribonucleic Acids in Disease Etiology and Drug Discovery

Sappy, Immaculate
http://rave.ohiolink.edu/etdc/view?acc_num=mco1566562465233197

Abstract Details

2019, Doctor of Philosophy (PhD), University of Toledo, Medicinal Chemistry.
Pseudouridine (Ψ), the 5-ribosyl isomer of uridine (U) is the most abundant nucleic acid modification found in all domains of life and all types of RNA. Studies have shown that, urinary levels of pseudouridine are higher in Alzheimer’s Disease (AD) patients and that RNA oxidation is a major component in the pathogenesis of Alzheimer’s Disease (AD) and other neurodegenerative disorders. Therefore, there is a potential correlation between higher urinary levels of pseudouridine in AD patients and oxidative stress. Hence, subjecting pseudouridine to oxidative conditions may provide some key information about the role of this nucleoside in RNA related processes and its role in disease etiology. Besides neurodegenerative disorders, antibiotic resistance is an additional threat to human health. Analogous to the development and use of nucleoside-analogue inhibitors (NAIs) of viral nucleotide polymerases for treatment of viruses, nucleotide analog inhibitors of bacterial RNA polymerase such as pseudouridimycin are also being investigated. These NAIs can limit bacterial resistance by mimicking the RNAP nucleoside triphosphate (NTP) binding site. To investigate these possibilities, the design, synthesis and characterization of pseudouridine analogs will be performed and these nucleosides will be evaluated for their antibacterial properties and their oxidative fate in RNA.
Amanda Bryant-Friedrich (Advisor)
Steven Peseckis (Committee Member)
Zahoor Shah (Committee Member)
Karen Steinmiller (Committee Member)
173 p.
Biomedical Research; Chemistry
RNA; DNA; Pseudouridine; Oxidative stress

Recommended Citations

Citations

  • Sappy, I. (2019). Ribonucleic Acids in Disease Etiology and Drug Discovery [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1566562465233197

    APA Style (7th edition)

  • Sappy, Immaculate. Ribonucleic Acids in Disease Etiology and Drug Discovery. 2019. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1566562465233197.

    MLA Style (8th edition)

  • Sappy, Immaculate. "Ribonucleic Acids in Disease Etiology and Drug Discovery." Doctoral dissertation, University of Toledo, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1566562465233197

    Chicago Manual of Style (17th edition)

mco1566562465233197
212
© 2019, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.