Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


HUIYING THESIS.pdf (3.5 MB)

ETD Abstract Container

Abstract Header

Anodized TiO2 Nanotube Film For Controllable Drug Delivery

Jia, Huiying
http://rave.ohiolink.edu/etdc/view?acc_num=miami1376435848

Abstract Details

2013, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
TiO2 nanotubes have great potential to improve the performance of Ti implants as a surface coating due to their high surface area, ability to promote bone growth and biocompatibility. However, there are two issues needed to be solved before further advancing TiO2 nanotubes technology as drug carrier: uncontrolled drug release and poor mechanical properties. In this study, a drug carrier using composite of biodegradable polymer/TiO2 nanotubes is engineered. Ibuprofen, carprofen and lidocaine were selected as test drugs. A simple characterization method is developed to investigate the infiltration of polymer into TiO2 nanotubes. The synthesized drug carrier demonstrated much better sustained drug release profile, greatly improved mechanical strength and flexibility compared to pure TiO2 nanotubes coating. It has also been found that the drug release kinetics using the synthesized drug carrier is controlled mainly by the drug solubility, polymer degradation and electrostatic force between drug and polymer which are pH dependent.
Lei Kerr (Advisor)
Shashi Lalvani (Committee Member)
Catherine Almquist (Committee Member)
54 p.
Chemical Engineering
Titanium dioxide nanotubes; drug delivery; biodegradable polymer; PLGA

Recommended Citations

Citations

  • Jia, H. (2013). Anodized TiO2 Nanotube Film For Controllable Drug Delivery [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1376435848

    APA Style (7th edition)

  • Jia, Huiying. Anodized TiO2 Nanotube Film For Controllable Drug Delivery. 2013. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1376435848.

    MLA Style (8th edition)

  • Jia, Huiying. "Anodized TiO2 Nanotube Film For Controllable Drug Delivery." Master's thesis, Miami University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1376435848

    Chicago Manual of Style (17th edition)

miami1376435848
2,032
© 2013, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.