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Full text release has been delayed at the author's request until July 26, 2024

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Role of BDNF in glial cell plasticity observed in the spinal cord following peripheral axon injury

Bhati, Sonia
http://rave.ohiolink.edu/etdc/view?acc_num=miami1564137726939359

Abstract Details

2019, Master of Science, Miami University, Cell, Molecular and Structural Biology (CMSB).
The overall goal of this project was to determine the role of brain derived neurotrophic factor (BDNF) in the microglia and astrocyte plasticity observed in the mouse spinal cord following peripheral axon injury. BDNF is known to play a role in neurodegeneration and, therefore, understanding the role of BDNF in glial cell plasticity presents an opportunity to identify therapeutic targets for several neurological disorders. A BDNF heterozygous mouse line with reduced BDNF was generated and plasticity at one week post injury was compared between wild-type and heterozygous mice. Reducing BDNF did not impact proliferation and short term microglia activation. However microglia that were formed during the first week post injury showed increased survival in the BDNF heterozygous mice suggesting a prolonged activation. Reduced BDNF did not impact GFAP protein expression, but increased baseline astrocyte activation. The findings from this study enhance our understanding of the influence of neurotrophin signaling on glial cell activity and provide insight for enhancing recovery after peripheral axon injury.
Lori Isaacson (Advisor)
72 p.
Neurosciences

Recommended Citations

Citations

  • Bhati, S. (2019). Role of BDNF in glial cell plasticity observed in the spinal cord following peripheral axon injury [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564137726939359

    APA Style (7th edition)

  • Bhati, Sonia. Role of BDNF in glial cell plasticity observed in the spinal cord following peripheral axon injury . 2019. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1564137726939359.

    MLA Style (8th edition)

  • Bhati, Sonia. " Role of BDNF in glial cell plasticity observed in the spinal cord following peripheral axon injury ." Master's thesis, Miami University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564137726939359

    Chicago Manual of Style (17th edition)

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© 2019, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.