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Ultrasound and exercise in skeletal muscle regeneration

Markert, Chad D.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1091304498

Abstract Details

2004, Doctor of Philosophy, Ohio State University, Physical Activity and Educational Services.
Objective: To determine whether non-thermal therapeutic ultrasound (US) and low-intensity exercise (Ex) influence skeletal muscle regeneration following a standardized contusion injury in an animal model. Hypothesis: Compared with the three other contusion injured treatment groups, which received exercise treatment alone (Ex+NoUS), ultrasound treatment alone (NoEx+US), and no treatment (NoEx+NoUS), the Ex+US group will exhibit an increase in measures of skeletal muscle regeneration. Design: Randomized control trial with blinded comparisons in a 2 X 2 factorial (ultrasound X exercise) design. Setting: Animal care facility/exercise physiology biochemistry laboratory. Participants: Twenty male Wistar rats (8 mo.) received a reproducible bilateral contusion injury to the gastrocnemius (GTN) muscles. Interventions: Ultrasound (parameters = 3 MHz, 0.1 W/cm2, 1cm2 transducer, 5 min duration/day) and exercise (20 min/day of low-intensity treadmill walking at 14 m/min). Main Outcome Measures: 96 hour post-injury muscle mass, contractile protein concentration, fiber cross-sectional area (CSAf), number of nuclei per fiber, and myonuclear density. Results: There was a statistical difference (p<0.05) between injured and non-injured GTN muscles in terms of myonuclei per fiber. There were no statistical differences (p<0.01) between the 4 treatment groups for any of the outcome measures chosen as biomarkers of skeletal muscle regeneration. Conclusions: The specific hypothesis was not supported. There is no evidence that the specific continuous ultrasound and exercise protocols investigated interact to enhance skeletal muscle regeneration following contusion injury.
Steven Devor (Advisor)
Ultrasound; Exercise; Muscle skeletal

Recommended Citations

Citations

  • Markert, C. D. (2004). Ultrasound and exercise in skeletal muscle regeneration [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1091304498

    APA Style (7th edition)

  • Markert, Chad. Ultrasound and exercise in skeletal muscle regeneration. 2004. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1091304498.

    MLA Style (8th edition)

  • Markert, Chad. "Ultrasound and exercise in skeletal muscle regeneration." Doctoral dissertation, Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1091304498

    Chicago Manual of Style (17th edition)

osu1091304498
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© 2004, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.