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osu1122916468.pdf (2.7 MB)
ETD Abstract Container
Abstract Header
Influence of post-injury ultrasound treatments on skeletal muscle regeneration
Author Info
McBrier, Nicole M
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1122916468
Abstract Details
Year and Degree
2005, Doctor of Philosophy, Ohio State University, Physical Activity and Educational Services.
Abstract
Non-thermal ultrasound (US) is commonly used in an attempt to improve tissue repair and regeneration, although the efficacy of this practice is not firmly established. Previous research has investigated only a few dependent variables at discreet points in time. Therefore, the purposes of these studies were to examine the influence of non-thermal ultrasound markers on skeletal muscle regeneration and to compare 4 different combinations of duty cycle and SAI representing two common SATA intensities. Design and Setting: Multifactorial designs comparing treatment, duty cycle, SATA, and time were used. A bilateral contusion injury to the gastrocnemius via a drop mass technique was performed. US administration commenced 24-hr post-injury and was delivered 5minutes daily on 4 consecutive days. Rats received the US treatment on their left hindlimb, and the contralateral right hindlimb served as a non-US control. Subjects: Male Wistar rats were used in this study and the protocol was ILACUC approved. Measurements: Dependent variables included muscle mass, fiber cross-sectional area, centrally localized nuclei, embryonic myosin heavy chain, MGF (muscle specific IGF-1), M-cadherin, and MyoD. Data were analyzed using a factorial MANOVA. Results: US increased muscle mass more than no treatment (P < 0.0001) and increases in muscle mass were found with the continuous US treatment compared to the pulsed duty cycle treatment at the same SATA (P = 0.019). In the second experiment, ultrasound treatments also statistically significantly affected MGF levels compared to non-treated hind limb (P = 0.029). There was an effect observed for the day post-injury for MGF (P = 0.014). Post-hoc testing revealed that the MGF value on 1 day post-injury was statistically greater than the values observed for days 3 and 4 after injury. Conclusions: The specific non-thermal ultrasound treatments we studied had beneficial effects on skeletal muscle regeneration following blunt trauma. When comparing US treatments providing identical energy delivery, a continuous duty cycle has a greater influence on skeletal muscle regeneration following blunt trauma than does a pulsed duty cycle.
Committee
Steven Devor (Advisor)
Pages
120 p.
Keywords
therapeutic ultrasound
;
modalities
;
contusion injury
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Citations
McBrier, N. M. (2005).
Influence of post-injury ultrasound treatments on skeletal muscle regeneration
[Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1122916468
APA Style (7th edition)
McBrier, Nicole.
Influence of post-injury ultrasound treatments on skeletal muscle regeneration.
2005. Ohio State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1122916468.
MLA Style (8th edition)
McBrier, Nicole. "Influence of post-injury ultrasound treatments on skeletal muscle regeneration." Doctoral dissertation, Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1122916468
Chicago Manual of Style (17th edition)
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Document number:
osu1122916468
Download Count:
1,123
Copyright Info
© 2005, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.