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Anesthetic efficacy of 4% articaine with 1:100,000 epinephrine, 4% prilocaine with 1:200,000 epinephrine, and 4% lidocaine with 1:100,000 epinephrine as a primary buccal infiltration of the mandibular first molar.

Nydegger, Brett
http://rave.ohiolink.edu/etdc/view?acc_num=osu1375785136

Abstract Details

2013, Master of Science, Ohio State University, Dentistry.
Previous studies have shown articaine to be superior to lidocaine when given as a primary buccal infiltration injection of the mandibular first molar. However, these studies compared 4% articaine to 2% lidocaine. No study has compared 4% lidocaine and 4% prilocaine to 4% articaine. Therefore, the purpose of this prospective, randomized, double-blind study was to compare three different 4% anesthetic solutions given as primary buccal infiltration injections adjacent to the mandibular first molar. Using a cross-over design, 60 adults received mandibular buccal infiltrations using 1.8 mL of 4% articaine with 1:100,000 epinephrine, 4% lidocaine with 1:100,000 epinephrine, and 4% prilocaine with 1:200,000 epinephrine at three separate appointments. An electric pulp tester was used to test the molars and premolars for pulpal anesthesia every 3 minutes for 60 minutes. Successful pulpal anesthesia was defined as two consecutive 80/80 readings. Pain ratings for each injection and post-operative pain were recorded. Data were statistically analyzed. For the first molar, the success rate for articaine was 55%, 33.3% for lidocaine, and 31.7% for prilocaine. There was a significant difference between articaine and both lidocaine (p=0.0259) and prilocaine (p=0.0094). There was no significant difference between lidocaine and prilocaine (p=1.0000). No differences were found for injection and post-injection pain. The anesthetic efficacy of articaine was better than lidocaine and prilocaine. This demonstrates that a 4% concentration of local anesthetic was not the important factor in pulpal anesthesia. It is likely the chemical structure of articaine that makes it a better anesthetic for mandibular buccal infiltrations.
John Nusstein, DDS, MS (Advisor)
Al Reader, DDS, MS (Committee Member)
Melissa Drum, DDS, MS (Committee Member)
Michael Beck, DDS, MA (Committee Member)
299 p.
Dentistry

Recommended Citations

Citations

  • Nydegger, B. (2013). Anesthetic efficacy of 4% articaine with 1:100,000 epinephrine, 4% prilocaine with 1:200,000 epinephrine, and 4% lidocaine with 1:100,000 epinephrine as a primary buccal infiltration of the mandibular first molar. [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1375785136

    APA Style (7th edition)

  • Nydegger, Brett. Anesthetic efficacy of 4% articaine with 1:100,000 epinephrine, 4% prilocaine with 1:200,000 epinephrine, and 4% lidocaine with 1:100,000 epinephrine as a primary buccal infiltration of the mandibular first molar. . 2013. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1375785136.

    MLA Style (8th edition)

  • Nydegger, Brett. "Anesthetic efficacy of 4% articaine with 1:100,000 epinephrine, 4% prilocaine with 1:200,000 epinephrine, and 4% lidocaine with 1:100,000 epinephrine as a primary buccal infiltration of the mandibular first molar. ." Master's thesis, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1375785136

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.