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Bovine Parainfluenza-3 Specific Antibodies in Veal Calves Supplemented with Cinnamaldehyde or Lactoferrin

Hogshead, Bradley Thomas
http://orcid.org/0000-0003-1614-4546
http://rave.ohiolink.edu/etdc/view?acc_num=osu1512121726642402

Abstract Details

2017, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
Bovine respiratory disease (BRD) causes severe economic losses to the beef and dairy cattle industries. It has multifactorial etiology that involves many host, pathogen, and environmental interactions. Enzootic pneumonia is one clinical presentation of BRD that is common in young calves; especially veal calves due to transport stress. Stress leaves calves susceptible to viruses, the initial respiratory pathogens. Bovine Parainfluenza-3 virus is a common virus that can initiate BRD. Adequate colostrum intake and vaccination help reduce disease risk, but do not eliminate it entirely. Prophylactic antibiotic treatment is common practice to prevent secondary bacterial infection; however, this can lead to antibiotic resistance. This study investigated the effect of two compounds, cinnamaldehyde (an essential oil from cinnamon) and lactoferrin (and iron-binding protein found in colostrum) on immune response to one pathogen associated with BRD (bovine parainfluenza-3 virus) as alternatives to antibiotic treatment. On arrival, calves (approximately 3 to 7 d of age) were randomized to one of three treatments (n = 80 per treatment): control (no supplement; CON), lactoferrin (1 g/d in milk replacer for 7 d; LAC), or cinnamaldehyde (1 g/d in milk replacer for 21 d; CIN) and divided equally between two barns (n = 120 per barn). Plasma anti-bPI3 IgG was assayed before (d 0) and 28 d after vaccination by indirect ELISA. Antibody titers were represented as Sample/Positive (S/P) ratio. A One-Way ANOVA was used to compare titers between treatments. A paired t-test was used to compare d 0 and d 28 antibody titers within treatments, and a Z-test was used to compare treatment groups between barns. Overall, antibody titers were significantly greater at d 0 than d 28 (P < 0.05) and no significant difference between treatment occurred at either time point. Similar results were observed in Barn 1 and Barn 2 compared to the overall results. However, antibody titers at d 0 in Barn 1 LAC calves tended to be greater than Barn 2 LAC calves (P = 0.08), and antibody titers in Barn 1 CON calves tended to greater than Barn 2 CON calves (P = 0.08). Results indicate no observable effect of treatment on antibody titers due to maternal interference of vaccine response. Further research is necessary to determine an optimal vaccination schedule to overcome maternal immunity in veal calves, as well as appropriate dose, duration, and route of administration of cinnamaldehyde and lactoferrin to enhance immunity to Bovine Parainfluenza-3 virus.
Renukaradhya Gourapura (Advisor)
Kathryn Proudfoot (Committee Member)
Gregory Habing (Committee Member)
65 p.
Animal Diseases; Animal Sciences; Immunology; Veterinary Services; Virology
Parainfluenza-3; bovine respiratory disease; BRD; cinnamaldehyde; lactoferrin

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Citations

  • Hogshead, B. T. (2017). Bovine Parainfluenza-3 Specific Antibodies in Veal Calves Supplemented with Cinnamaldehyde or Lactoferrin [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512121726642402

    APA Style (7th edition)

  • Hogshead, Bradley. Bovine Parainfluenza-3 Specific Antibodies in Veal Calves Supplemented with Cinnamaldehyde or Lactoferrin. 2017. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1512121726642402.

    MLA Style (8th edition)

  • Hogshead, Bradley. "Bovine Parainfluenza-3 Specific Antibodies in Veal Calves Supplemented with Cinnamaldehyde or Lactoferrin." Master's thesis, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512121726642402

    Chicago Manual of Style (17th edition)

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