Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


Rowe Masters Thesis.pdf (1.6 MB)

ETD Abstract Container

Abstract Header

Targeting Neutrophils to Improve Protection by Sublingual Vaccines

Rowe, John Christopher
http://orcid.org/0000-0002-6662-2983
http://rave.ohiolink.edu/etdc/view?acc_num=osu1612190976457585

Abstract Details

2021, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
Vaccines are biological preparations that are used to educate the immune system and make it develop a long lasting or adaptive immunity directed specifically against one or several components of the preparations. Vaccines containing parts or components of disease-causing microorganism have been used in medical science for over 300 years in a variety of capacities to help control the burden of infectious diseases in both humans and animals. Indeed, new frontiers continue to emerge regarding broader applications of vaccination, including novel approaches to treat cancer or ways to prevent future obesity. More specific to infectious diseases, most infectious agents enter the host via exposed mucosal surfaces and the development of novel vaccination approaches to successfully protect both the general bloodstream and mucosal tissues is vital to protecting public health in the modern era. In this thesis, a novel approach to improve the efficacy of mucosal vaccination is described using a sublingual vaccine model. Neutrophils are the main myeloid cell subset found in the body and are among the first cells recruited to sites of inflammation, or vaccination. This thesis describes how the supplementation of a sublingual vaccine with molecules that suppress neutrophil elastase improves the kinetic of subsequent antibody responses and leads to the production of broad antibody responses, including secretory IgA at mucosal tissue sites, and is accompanied by broad helper T cell induction.
Prosper Boyaka, PhD (Advisor)
Abhay Satoskar, MD, PhD (Committee Member)
Renukaradhya Gourapura, DVM, PhD (Committee Member)
64 p.
Immunology
vaccine; sublingual vaccine; mucosal vaccination; IgA; neutrophil; elastase; neutrophil elastase inhibitor; NEI; alvelestat; Bacillus anthracis

Recommended Citations

Citations

  • Rowe, J. C. (2021). Targeting Neutrophils to Improve Protection by Sublingual Vaccines [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1612190976457585

    APA Style (7th edition)

  • Rowe, John. Targeting Neutrophils to Improve Protection by Sublingual Vaccines. 2021. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1612190976457585.

    MLA Style (8th edition)

  • Rowe, John. "Targeting Neutrophils to Improve Protection by Sublingual Vaccines." Master's thesis, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1612190976457585

    Chicago Manual of Style (17th edition)

osu1612190976457585
94
© 2021, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.