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Role of Cell-Type Specific Interleukin-1 Receptor Type 1 Signaling in Lasting Neuroinflammation: The Good, The Bad, and The Irrelevant

Nemeth, Daniel Paul
http://orcid.org/0000-0002-0693-343X
http://rave.ohiolink.edu/etdc/view?acc_num=osu1637752320066739

Abstract Details

2021, Doctor of Philosophy, Ohio State University, Oral Biology.
Inflammation within the central nervous system (CNS) is called “neuroinflammation” and, depending on the context, i.e. magnitude, duration, stimulus type, can cause beneficial or detrimental consequences. The innate immune cells within the CNS that influence the properties of neuroinflammation are the microglia; making microglia targets to understand how CNS immune responses relate to damage or reparative processes. A key molecule that microglia produce is Interleukin-1 (IL-1)—a master cytokine that can initiate all aspects of the inflammatory processes. IL-1 is known to induce both adverse and beneficial effects on CNS processes; however, how these diametrically opposite results arise from a single immune molecule are unknown. To understand how IL-1 signaling can result in protective and destructive outcomes, a double knock-in mouse model which restricts the expression of the cognate receptor for IL-1, Interleukin-1 Receptor Type 1 (IL-1R1), to a specific cell type was used. In this dissertation, multiple models of lasting neuroinflammation were used to dissect how cell type-specific IL-1/IL-1R1 signaling can cause neuroprotection or neuropathologies. Chapters 1 and 2 show that a model of systemic inflammation induced-neuroinflammation initiates a neuroprotective environment within the CNS via the endothelial and microglial IL-1R1. In Chapter 3, chronically expressed IL-1 can induce anti-neurogenic responses that are mediated via endothelial and myeloid IL-1R1, but not the adjacent neuronal IL-1R1. Finally, Chapter 4 investigates how neuronal IL-1R1 influences seizure severity and neuronal activation patterns following induction of epilepsy. These findings highlight the biological mechanisms through which cell type-specific IL-1R1 causes a variety of neuroinflammatory responses.
John Sheridan (Advisor)
Ning Quan (Advisor)
190 p.
Immunology; Neurobiology; Neurosciences
neuroinflammation, microglia, BBB, epilepsy

Recommended Citations

Citations

  • Nemeth, D. P. (2021). Role of Cell-Type Specific Interleukin-1 Receptor Type 1 Signaling in Lasting Neuroinflammation: The Good, The Bad, and The Irrelevant [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1637752320066739

    APA Style (7th edition)

  • Nemeth, Daniel. Role of Cell-Type Specific Interleukin-1 Receptor Type 1 Signaling in Lasting Neuroinflammation: The Good, The Bad, and The Irrelevant. 2021. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1637752320066739.

    MLA Style (8th edition)

  • Nemeth, Daniel. "Role of Cell-Type Specific Interleukin-1 Receptor Type 1 Signaling in Lasting Neuroinflammation: The Good, The Bad, and The Irrelevant." Doctoral dissertation, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1637752320066739

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.
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