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Contribution of ICAM-1 to the Immunobiology of Skeletal Muscle Hypertrophy

Dearth, Christopher L.
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302277138

Abstract Details

2011, Doctor of Philosophy, University of Toledo, College of Health Sciences.
Our laboratory recently demonstrated that β2 integrins, adhesion molecules expressed by myeloid cells, contribute to the hypertrophic response to muscle overload. The present study was conducted to gain insight into the possibility that β2 integrins promote hypertrophy via a mechanism that is dependent on the expression of ICAM-1, a major ligand for the β2 integrin CD11b/CD18. We found that muscle overload increased gene and protein expression of ICAM-1 and induced ICAM-1 expression by both myofibers and satellite cells/myoblasts via a β2 integrin independent mechanism. Functionally, in-vitro studies demonstrated that activation of ICAM-1 promotes the events of proliferation and hypertrophy in skeletal muscle cells. These results are supported by additional in-vivo experiments which demonstrated that ICAM-1 contributes to skeletal muscle hypertrophy as indicated by greater elevations in muscle mass, myofiber size, and protein content in wild type compared to ICAM-1-/- mice after muscle overload. The cumulative interpretation of the results presented herein give credence to our working model which hypothesized that expression of ICAM-1 by skeletal muscle cells after mechanical loading serves as a mechanism by which neutrophils and macrophages can bind to and directly communicate with skeletal muscle cells to promote hypertrophy.
Francis Pizza, PhD (Committee Chair)
Thomas McLoughlin, PhD (Committee Member)
Douglas Leaman, PhD (Committee Member)
Anthony Quinn, PhD (Committee Member)
127 p.
Biology; Cellular Biology; Health Sciences; Immunology; Kinesiology; Physiology
skeletal muscle; physiology; inflammation; inflammatory response; resistance training; exercise; satellite cell; myofiber; ICAM-1

Recommended Citations

Citations

  • Dearth, C. L. (2011). Contribution of ICAM-1 to the Immunobiology of Skeletal Muscle Hypertrophy [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302277138

    APA Style (7th edition)

  • Dearth, Christopher. Contribution of ICAM-1 to the Immunobiology of Skeletal Muscle Hypertrophy. 2011. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302277138.

    MLA Style (8th edition)

  • Dearth, Christopher. "Contribution of ICAM-1 to the Immunobiology of Skeletal Muscle Hypertrophy." Doctoral dissertation, University of Toledo, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302277138

    Chicago Manual of Style (17th edition)

toledo1302277138
747
© 2011, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.