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Characterization of a Novel Mouse Model for Angiosarcoma in Which Combined Inhibition of mTOR and MEK Results in Tumor Suppression

Chadwick, Michelle
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490353768809798

Abstract Details

2017, PhD, University of Cincinnati, Medicine: Cancer and Cell Biology.
Angiosarcoma is a rare malignancy of the endothelium, making up about 2% of sarcoma diagnoses. The causes of this disease are relatively unknown, especially in the pediatric population. Currently, the best treatment for angiosarcoma is complete surgical resection. If complete resection is unachievable due to anatomic location, chemotherapeutics are used, although these are not very effective. Five year median survival remains poor around 31-43%. As angiosarcoma is so rare, there has been little research done regarding the pathogenesis of the disease. There is a lack of model systems in which to study angiosarcoma in order to develop novel therapeutic strategies.
Lionel Chow, M.D. Ph.D. (Committee Chair)
Elisa Boscolo, Ph.D. (Committee Member)
Biplab Dasgupta, Ph.D. (Committee Member)
James Driscoll, M.D. Ph.D. (Committee Member)
Nicolas Nassar, Ph.D. (Committee Member)
174 p.
Biology
PTPN12; Angiosarcoma; mTOR; MAPK

Recommended Citations

Citations

  • Chadwick, M. (2017). Characterization of a Novel Mouse Model for Angiosarcoma in Which Combined Inhibition of mTOR and MEK Results in Tumor Suppression [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490353768809798

    APA Style (7th edition)

  • Chadwick, Michelle. Characterization of a Novel Mouse Model for Angiosarcoma in Which Combined Inhibition of mTOR and MEK Results in Tumor Suppression. 2017. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490353768809798.

    MLA Style (8th edition)

  • Chadwick, Michelle. "Characterization of a Novel Mouse Model for Angiosarcoma in Which Combined Inhibition of mTOR and MEK Results in Tumor Suppression." Doctoral dissertation, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490353768809798

    Chicago Manual of Style (17th edition)

ucin1490353768809798
448
© 2017, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.