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High Sugar Consumption Results in Mammary Epithelial Hyperplasia and Adipocyte Hypertrophy in a Mouse Model of Hyperglycemia

Sharma, Puja
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268272488285

Abstract Details

2020, MS, University of Cincinnati, Medicine: Biomedical Research Technology.
Increasing evidence has shown the impact of external factors on increased cancer risk. The chances of being diagnosed with breast cancer increases in female patients diagnosed with diabetes and/or obesity. Lifestyle behaviors, such as diet, can impact the anatomy of the mammary gland, but the exact mechanism is not well known. In this study, we explore the anatomical changes that arise in the mammary gland in response to an unhealthy diet, specifically studying the adipocytes and epithelial cells of the mammary glands. Our hyperglycemic mouse model showed signs of diabetes and obesity and has higher risk factors for breast cancer. In addition, not only was there a reversal in obesity and diabetic phenotypes, but also in adipocyte hypertrophy. Quantification of the mammary gland lobules and proliferation showed irreversible epithelial hyperplasia. We believe that this preliminary data will lead to further studies that focuses on identifying a mechanistic link between hyperglycemia and cancer.
Anjaparavanda Naren, Ph.D. (Committee Chair)
Biplab DasGupta, Ph.D. (Committee Member)
Takahisa Nakamura, Ph.D. (Committee Member)
15 p.
Molecular Biology
hyperglycemia; cancer; mammary gland

Recommended Citations

Citations

  • Sharma, P. (2020). High Sugar Consumption Results in Mammary Epithelial Hyperplasia and Adipocyte Hypertrophy in a Mouse Model of Hyperglycemia [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268272488285

    APA Style (7th edition)

  • Sharma, Puja. High Sugar Consumption Results in Mammary Epithelial Hyperplasia and Adipocyte Hypertrophy in a Mouse Model of Hyperglycemia. 2020. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268272488285.

    MLA Style (8th edition)

  • Sharma, Puja. "High Sugar Consumption Results in Mammary Epithelial Hyperplasia and Adipocyte Hypertrophy in a Mouse Model of Hyperglycemia." Master's thesis, University of Cincinnati, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268272488285

    Chicago Manual of Style (17th edition)

ucin1593268272488285
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