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Effects of Synthetic Ligands on Heterodimer Pairs Regarding Full-Length Human PPARa, RXRa and LXRa

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2016, Master of Science (MS), Wright State University, Biochemistry and Molecular Biology.
Nuclear receptor study is critically relevant in therapeutic medicine since the intricate details of disease states pertaining to atherosclerosis and diabetes are poorly understood. Three nuclear receptors of interest regulate target genes pertaining to cholesterol and fatty acid regulation, linking these receptors to therapeutic medicine. The first is the peroxisome proliferator-activated receptor alpha (PPARa), which resides in liver and muscle, coordinating lipoprotein and fatty acid homeostasis [1]. Cholesterol homeostasis is dictated by the liver X receptor alpha (LXRa), targeting genes pertaining to the kidney, intestine, liver and adipose tissues [2]. A common partner receptor to PPARa and LXRa is known as the retinoid X receptor alpha (RXRa) [3]. Although each receptor appears unique in function, the cause and effects of disease states are poorly understood due to the promiscuous nature of these receptor proteins. These particular receptors can form permissive heterodimers where metabolic effects can be manipulated by ligands [3]. Accordingly, clinical care becomes increasingly complex as synthetic ligands made to target one receptor could have additional repercussions. With respect to therapeutic medicine, ligand binding may not be exclusive. Therefore, it becomes necessary to study synthetic ligands with each receptor, individually and in heterodimeric form, to further understand the complex regulation and clinical implications of synthetic ligands on disease states such as atherosclerosis and diabetes.
Dean Rider, Jr., Ph.D. (Advisor)
Lawrence Prochaska, Ph.D. (Committee Member)
Weiwen Long, Ph.D. (Committee Member)
Steven Berberich, Ph.D. (Committee Member)
108 p.

Recommended Citations

Citations

  • Delman, E. (2016). Effects of Synthetic Ligands on Heterodimer Pairs Regarding Full-Length Human PPARa, RXRa and LXRa [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472204976

    APA Style (7th edition)

  • Delman, Emily. Effects of Synthetic Ligands on Heterodimer Pairs Regarding Full-Length Human PPARa, RXRa and LXRa. 2016. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1472204976.

    MLA Style (8th edition)

  • Delman, Emily. " Effects of Synthetic Ligands on Heterodimer Pairs Regarding Full-Length Human PPARa, RXRa and LXRa." Master's thesis, Wright State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472204976

    Chicago Manual of Style (17th edition)