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RESISTIVE PULSE SENSORS FOR POLLEN PARTICLE MEASUREMENTS

Zhang, Zheng
http://rave.ohiolink.edu/etdc/view?acc_num=akron1145070142

Abstract Details

2006, Master of Science, University of Akron, Mechanical Engineering.
Micro-Coulter counter is a device that allows measurements number and size of particles in the electrolyte. The sensor measures the electrical resistance of a micro-channel that connects two solution-filled reservoirs. When a particle passes through the micro-channel, it displaces conducting electrolyte, thus a transient resistive pulse of the pore resistance is generated. The magnitude and the duration of the pulse is related to the size, surface charge and mobility of the particle that caused it. We have developed a prototype resistive pulse sensor, and measurement system platform for performing pollen and micro-particle analysis. We used the device with a single micro-channel with 120µm to measure 20µm and 40µm polymethyl methacrylate (PM) particles and then to detect pollen particles in various KCL concentrations. We experimentally demonstrated the theoretical relation between the particle geometry and the pulse height with 20 µm and 40 µm polymethyl methacrylate particles. For the first time we found that the resistance of the electrolyte-filled micro-channel decreases rather than increases when a pollen particle passes through the micro-channel in low ionic concentration solutions. The phenomena might be attributed to the differences between the surface properties of the pollens and polymethyl methacrylate (PM) particles, and is potentially useful for differentiating and counting different pollen particles. In order to address the long standing problem of long-standing disadvantages of traditional single-channel resistive-pulse sensors, namely low throughput, we demonstrated a multi-channel resistive sensor that is able to detect the micro-particles through its multiple micro scale sensing channels. The usage of multiple channels allows a large volume of sample solutions to be analyzed at one time. Thus the sensing efficiency was improved multiple times. The multi-channel sensing mode was achieved by miniaturization and integration of micro-fluidic channels into one chip, without sacrificing the sensitivity. The resistive pulses due to particles passing each micro-channel were recorded simultaneously and continuously. Our preliminary experimental results on multi-channel sensor indicated that it is feasible for the future development of high throughput micro-machined device that integrates micro-fluidic channels, multiple sensing channels and multiplexed detection for pollen and other bio-particle analysis.
Jiang Zhe (Advisor)
MEMS; Micro-Coulter counter; Resistive pulse sensor

Recommended Citations

Citations

  • Zhang, Z. (2006). RESISTIVE PULSE SENSORS FOR POLLEN PARTICLE MEASUREMENTS [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1145070142

    APA Style (7th edition)

  • Zhang, Zheng. RESISTIVE PULSE SENSORS FOR POLLEN PARTICLE MEASUREMENTS. 2006. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1145070142.

    MLA Style (8th edition)

  • Zhang, Zheng. "RESISTIVE PULSE SENSORS FOR POLLEN PARTICLE MEASUREMENTS." Master's thesis, University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1145070142

    Chicago Manual of Style (17th edition)

akron1145070142
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© 2006, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.