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The Synthesis, Characterization, and Antitumor Properties of Ag(I), Cu(II), and Rh(III) Metal Complexes

Medvetz, Douglas Allen
http://rave.ohiolink.edu/etdc/view?acc_num=akron1216840371

Abstract Details

2008, Doctor of Philosophy, University of Akron, Chemistry.
The anticancer drug cisplatin, which has been approved to treat ovarian, testicular, head and neck, certain types of lung, and metastatic breast cancers, has been a major advancement in cancer therapy. However, severe side effects including nausea, ear damage, vomiting, sensation loss in the extremities, and liver and kidney toxicity are usually experienced leading to the discontinuation of therapy. Along with the toxic side effects, resistance to this drug has become a major disadvantage. Due to these factors various other platinum derivatives have been explored leading to the discovery of carboplatin. Though carboplatin is quite active it still carries many of the same limitations as cisplatin, leading to the conclusion that the use of non-platinum metal complexes is essential. To date complexes of silver, rhodium, ruthenium, iron, copper, rhenium, titanium, and gold have shown promising results which may lead to the divergence from platinum based drugs. This dissertation describes the synthesis, characterization, and anticancer properties of a variety of metal complexes. These include Ag(I) metal complexes along with a Cu(II) and a Rh(III) metal complex. Chapter 1 of this dissertation discusses a vast majority of the work that has been previously explored using non-platinum metal complexes as anticancer agents. Chapter 2 is devoted to the anticancer properties of three N-Heterocyclic carbene Ag(I) complexes. These complexes have shown anticancer properties in vitro against ovarian, breast, melanoma, colon carcinoma, and renal carcinoma cell lines with one of the complexes possessing preliminary in vivo anticancer properties against an ovarian cancer xenograft model. Chapter 3 is devoted to the synthesis, characterization, and in vitro anticancer properties of a Cu(II) thiaether complex and a Rh(III) thiaether complex against ovarian, breast, and lung cancer cell lines. Both complexes are active, however, the Cu(II) complex is more efficacious. Chapter 4 describes the synthesis and characterization of a variety of new imidazolium salts, which are the precursors to N-Heterocyclic carbenes, and some of their respective N-Heterocyclic carbene Ag(I) metal complexes that may have future use as anticancer agents.
Wiley Youngs, PhD (Advisor)
Claire Tessier, PhD (Advisor)
225 p.
Chemistry
cisplatin; Cl; COMPLEXES; anticancer; Rh; silver

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Citations

  • Medvetz, D. A. (2008). The Synthesis, Characterization, and Antitumor Properties of Ag(I), Cu(II), and Rh(III) Metal Complexes [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1216840371

    APA Style (7th edition)

  • Medvetz, Douglas. The Synthesis, Characterization, and Antitumor Properties of Ag(I), Cu(II), and Rh(III) Metal Complexes. 2008. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1216840371.

    MLA Style (8th edition)

  • Medvetz, Douglas. "The Synthesis, Characterization, and Antitumor Properties of Ag(I), Cu(II), and Rh(III) Metal Complexes." Doctoral dissertation, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1216840371

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.