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akron1289857293.pdf (1.5 MB)
ETD Abstract Container
Abstract Header
Recombinant Expression of Sry3 Raises Blood Pressure Indices in Rattus norvegicus
Author Info
Boehme, Shannon M.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=akron1289857293
Abstract Details
Year and Degree
2010, Master of Science, University of Akron, Biology.
Abstract
The Y chromosome of the spontaneously hypertensive rat contains a gene responsible for a 20-25 mmHg increase in blood pressure. The sex-determining region on the Y chromosome (Sry) has been implicated in this increase. The Sry3 locus is unique to the SHR Y chromosome and increases reporter activity of multiple renin angiotensin system genes. The current study exogenously delivered Sry3 to the left kidney of normotensive, WKY rats. After a blood pressure rise was seen and plasma renin activity increased, the angiotensin type 1 receptor was blocked with olmesartan medoximil and blood pressure dropped, followed by an inhibition of plasma renin activity.
Committee
Daniel Ely, Dr. (Advisor)
Monte Turner, Dr. (Committee Member)
Rolando Ramirez, Dr. (Committee Member)
Pages
60 p.
Subject Headings
Biology
Keywords
Sry
;
Hypertension
;
Renin Angiotensin System
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Citations
Boehme, S. M. (2010).
Recombinant Expression of Sry3 Raises Blood Pressure Indices in Rattus norvegicus
[Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1289857293
APA Style (7th edition)
Boehme, Shannon.
Recombinant Expression of Sry3 Raises Blood Pressure Indices in Rattus norvegicus.
2010. University of Akron, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=akron1289857293.
MLA Style (8th edition)
Boehme, Shannon. "Recombinant Expression of Sry3 Raises Blood Pressure Indices in Rattus norvegicus." Master's thesis, University of Akron, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1289857293
Chicago Manual of Style (17th edition)
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Document number:
akron1289857293
Download Count:
436
Copyright Info
© 2010, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.