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Synthesis and Characterization of Amino Acid-based Poly(ester urea)

Yu, Jiayi
http://orcid.org/0000-0003-3697-9137
http://rave.ohiolink.edu/etdc/view?acc_num=akron1366901855

Abstract Details

2013, Master of Science, University of Akron, Polymer Science.
Bone defects are considered one of the most significant problems in orthopedic surgery. Approximately 1.62 million surgical bone graft procedures were performed in the United States in 2005 and 672,000 fracture reductions in 2006. Although autograft, allograft and some synthetic bone graft materials such as bioceramics and biometallic-based scaffolds have been used successfully for bone defect repair, these materials are not ideal due to their limited supply, bioactivity and insufficient mechanical properties. In this study, we synthesized and characterized amino acid-based poly(ester urea)s for creating bioactive, load-bearing polymeric materials designed to restore function within critical-sized bone defects. Our preliminary data has shown that 1,6-hexanediol phenylalanine-based poly(ester urea)s possess mechanical properties nearly double that of poly(lactic acid) and potent osteoinductive activity. This thesis investigates the diol chain length in the polymer synthesis and its influence on the mechanical properties and in vitro biodegradation, which is the primary innovation of this work. The tunable diol chain length affords optimization of material modulus and in vitro biodegradation rate for the long bone defect repair. These novel biodegradable and non-toxic poly(ester urea)s offer a cost effective solution to the current technologies, the reinforcement of mechanical properties and aid in the healing process making them attractive alternatives to current treatments for bone defects.
Matthew Becker, Dr. (Advisor)
Abraham Joy, Dr. (Committee Member)
80 p.
Biomedical Engineering; Polymer Chemistry; Polymers
bone graft; polymer; poly ester urea; diol chain length; Youngs Modulus; biodegradation

Recommended Citations

Citations

  • Yu, J. (2013). Synthesis and Characterization of Amino Acid-based Poly(ester urea) [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1366901855

    APA Style (7th edition)

  • Yu, Jiayi. Synthesis and Characterization of Amino Acid-based Poly(ester urea). 2013. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1366901855.

    MLA Style (8th edition)

  • Yu, Jiayi. "Synthesis and Characterization of Amino Acid-based Poly(ester urea)." Master's thesis, University of Akron, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1366901855

    Chicago Manual of Style (17th edition)

akron1366901855
724
© 2013, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.
Release 3.2.12