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Fabrication of PPF Based Drug Containing Microneedle Arrays by Microstereolithography

Mantha, Satya Nymisha
http://rave.ohiolink.edu/etdc/view?acc_num=akron1374434592

Abstract Details

2013, Master of Science, University of Akron, Mechanical Engineering.
Transdermal drug delivery systems are one of the impetus areas in drug delivery research due to their distinguished advantages over oral and hypodermicneedles. Microneedle based transdermal drug delivery system is one of the emerging devices for drug delivery in recent years. Microneedles deliver drug into the epidermis without disrupting the nerves endings. Many researchers have designed different microneedles and have fabricated those using different materials and fabrication processes. In this current work, microneedles were fabricated using a biodegradable and biocompatible polymer poly(propylene fumarate) (PPF), which is being recently used for different biomedical applications. The fabrication process adopted in this work was microstereolithography which is an emerging 3D microfabrication process that is being explored in biomedical applications since few years. An attempt was made to fabricate PPF based microneedle arrays containing drug (BSA) using microstereolithography process. To obtain these microneedle arrays, firstly PPF was synthesized and characterized, and then different prepolymers were prepared using PPF and different ratios of drug for the fabrication. The microstereolithography system that was used for fabrication was developed, calibrated and verified. Since these materials are new, their material properties such as viscosity, cure depth and exposure time, and mechanical properties such as elastic modulus and ultimate compressive strength were obtained by conducting different experiments. Finally, the microneedles arrays were fabricated and were characterized using a microscope and scanning electron microscope.
Jae-Won Choi, Dr. (Advisor)
Srivatsan Tirumalai, Dr. (Committee Member)
Erik Engeberg, Dr. (Committee Member)
134 p.
Mechanical Engineering; Medicine

Recommended Citations

Citations

  • Mantha, S. N. (2013). Fabrication of PPF Based Drug Containing Microneedle Arrays by Microstereolithography [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374434592

    APA Style (7th edition)

  • Mantha, Satya Nymisha. Fabrication of PPF Based Drug Containing Microneedle Arrays by Microstereolithography . 2013. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1374434592.

    MLA Style (8th edition)

  • Mantha, Satya Nymisha. "Fabrication of PPF Based Drug Containing Microneedle Arrays by Microstereolithography ." Master's thesis, University of Akron, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374434592

    Chicago Manual of Style (17th edition)

akron1374434592
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© 2013, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.