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Design Of Multi-Drug Release Coaxial Electrospun Mat Targeting Infection And Inflammation

Wen, Shihao
http://rave.ohiolink.edu/etdc/view?acc_num=akron1468852133

Abstract Details

, Master of Science, University of Akron, Polymer Engineering.
Although inflammation and infection commonly coexist in the wound, there is a paucity of suitable methods to localized delivery of antibiotics and anti-inflammatory drugs at appropriate timescales and concentrations. Due to the high level of getting injured in battle field, great attention should be given to loss of blood and the potential infection of wound areas. A simple, portable method is required to give first aid to the wounded area within short time to address potential infection and efficiently promote the wound healing process. In this project, we developed a versatile core-shell electrospun mats by using biocompatible materials in aqueous solution, silk protein polymers, which is known to be non-toxic to apply on human skin with excellent mechanical strength and controllable biodegradability. The coaxial electrospinning techniques are used to fabricate multilayer structured electrospun mats to incorporate anti-inflammatory (Flurbiprofen) and anti-bacterial (Vancomycin) agents to achieve desirable multi-drug release profiles at different time scales. Electrospinning parameters such as applied voltage, tip-collector distance and flow rate are used to optimize mechanical properties and release kinetics. Several different mat configurations were also designed to further modulate overall properties of multifunctional electrospun mats. The changes in secondary structures in the course of incubation were identified by Fourier transform infrared spectroscopy (FT-IR). While Differential scanning calorimetry (DSC) was performed to study the extraction of PEO inside the electrospun nanofibers during incubation. Instron was carried out to investigate mechanical property of the electrospun mat. A wide range of drug release profiles were obtained by high performance liquid chromatography (HPLC). We observed two different release rates composed of a relatively fast release of Flurbiprofen with final loadings of 8 to 14 µg/cm2 within a few days, together with a sustained release of Vancomycin with final loadings of 35 to 70 µg/cm2 for up to 20 days. Overall, this project addresses a strong need on the short-term remediation and long-term wound healing process. The approach developed in this project can be further expanded for other drug delivery problems that require a programmable delivery of variable therapeutics over multiple days.
Min Younjin (Advisor)
Darrell Reneker, H. (Committee Chair)
Alamgir Karim (Committee Member)
Polymers
Electrospinning; Bombyx mori silk;

Recommended Citations

Citations

  • Wen, S. (2016). Design Of Multi-Drug Release Coaxial Electrospun Mat Targeting Infection And Inflammation [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1468852133

    APA Style (7th edition)

  • Wen, Shihao. Design Of Multi-Drug Release Coaxial Electrospun Mat Targeting Infection And Inflammation. 2016. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1468852133.

    MLA Style (8th edition)

  • Wen, Shihao. "Design Of Multi-Drug Release Coaxial Electrospun Mat Targeting Infection And Inflammation." Master's thesis, University of Akron, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1468852133

    Chicago Manual of Style (17th edition)

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© 2016, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.