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A Multiscale Framework to Analyze Tricuspid Valve Biomechanics

THOMAS, VINEET SUNNY
http://rave.ohiolink.edu/etdc/view?acc_num=akron1542255754172363

Abstract Details

2018, Doctor of Philosophy, University of Akron, Biomedical Engineering Specialization.
The structure and composition of the extracellular matrix (ECM) fiber networks are closely tied to an overall biomechanical function of soft tissues such as heart valves. In particular, in the tricuspid valve (TV), due to various pathological conditions that require surgical interventions, the prevailing mechanical loading environment is modified. Such changes in the TV mechanical loading may induce alteration in the ECM structure and composition over time. Hence, there is a need to understand the long-term effects of such remodeling responses on the functioning capacity of the TV. This project framework clearly identifies the link among the ECM microstructural architecture, micro-scale biomechanics and the macro-scale mechanical responses of the TV leaflets. Such knowledge of multi-scale TV biomechanics is necessary to predict TV responses when subjected to modified mechanical loading environment as a result of a TV repair surgery or other prevailing valve pathologies. While previous studies have addressed the biomechanical behavior and complex geometry of the mitral valve and the aortic valve, the TV, which was once considered “the forgotten valve”, has not been studied thoroughly. The TV, however, has received much attention in recent years due to efforts in increasing long-term survival of pa- tients post TV surgeries. Computational models are effective tools to obtain insights regarding biomechanical changes in the valve following surgical procedures. However, currently the two available computational models of TV have been constructed based on a grossly simplified geometry and homogenous mechanical properties of the MV. Without a microstructurally and mechanically accurate model of the TV, conducting hypothesis-driven studies of valve pathologies, enhancing surgical procedures and improving treatment strategies are hindered. As such, we build a micro-structurally faithful model that includes contributions of cells, disorganized matrix, and organized fibers, which can predict the behavior of the TV leaflets.
Rouzbeh Amini (Advisor)
Brian Davis (Committee Member)
Marnie Saunders (Committee Member)
Francis Loth (Committee Member)
Rolando Ramirez (Committee Member)
Atef Saleeb (Committee Member)
262 p.
Biomechanics; Biomedical Engineering; Engineering; Health; Mechanics; Teaching
multiscale modeling; tricuspid valve; averaging; anterior leaflet; posterior leaflet; septal leaflet; tricuspid regurgitation; heart valve; cell deformation; NAR; pulmonary hypertension; microscale; fiber network; SALS; biaxial tension; contraction; pressure

Recommended Citations

Citations

  • THOMAS, V. S. (2018). A Multiscale Framework to Analyze Tricuspid Valve Biomechanics [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1542255754172363

    APA Style (7th edition)

  • THOMAS, VINEET. A Multiscale Framework to Analyze Tricuspid Valve Biomechanics. 2018. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1542255754172363.

    MLA Style (8th edition)

  • THOMAS, VINEET. "A Multiscale Framework to Analyze Tricuspid Valve Biomechanics." Doctoral dissertation, University of Akron, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1542255754172363

    Chicago Manual of Style (17th edition)

akron1542255754172363
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© 2018, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.