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A NOVEL CHITOSAN-BASED WOUND HEALING HYDROGEL FOR THE ENHANCEMENT OF LOCAL OXYGEN LEVELS AND FOR THE FACILITATION OF DERMAL TISSUE REPAIR

Fountas-Davis, Natalie D
http://orcid.org/0000-0003-2490-2247
http://rave.ohiolink.edu/etdc/view?acc_num=akron155567641759327

Abstract Details

2019, Master of Science in Engineering, University of Akron, Biomedical Engineering.
Wound healing is a challenge not specific to a particular demographic. It affects all areas of the world and is the result of many different disease types and scenarios. There is a vast array of sources for disease initiation in wound healing and the field currently lacks simple and effective solutions for remedying the ailment. Oxygen is an essential component required in many of the biochemical processes occurring during the wound healing process and many chronic wounds lack oxygen resulting in wounds that do not heal or heal too slowly. A wound healing hydrogel, methacrylated fluorinated (Ali15) chitosan (MAC) also known as MAC(Ali15)F, was developed and characterized in an attempt to enhance local oxygen concentrations in oxygen-deficient skin. More specifically, this chitosan-based hydrogel used Schiff base nucleophilic substitution to attach perfluorocarbons (PFCs), which are known for their ability to capture oxygen from the surrounding atmosphere. Material characterization studies showed the MAC(Ali15)F hydrogel's ability to release oxygen, to sustain lysozyme concentrations of 1000 U/mL, and to retain the ability after degradation to sequester oxygen. The MAC(Ali15)F hydrogel showed evidence of biocompatibility when exposed to human dermal fibroblasts and in rodent studies. In vitro studies established that the hydrogels encouraged cell proliferation. In vivo studies indicated that the wounds being treated with hydrogels were able to progressively heal in a moist environment. Preliminary studies show that the hydrogels have the potential to provide specific levels of oxygen to the wound site while simultaneously providing moisture for wounds in a portable and customizable bandage size.
Nic Leipzig, Ph.D. (Advisor)
Brian Davis, Ph.D. (Committee Member)
Judith Fulton, Ph.D. (Committee Member)
Rebecca Kuntz-Willits, Ph.D. (Committee Member)
89 p.
Biomedical Engineering; Chemical Engineering
hydrogel, oxygen, chronic wound healing, wound healing, delayed healing, therapeutics, dermis, epidermis, skin, reepithelialization, fibroblast, wound closure, diabetes, comorbidity, fluorination, fluorine, chitosan, methacrylamide

Recommended Citations

Citations

  • Fountas-Davis, N. D. (2019). A NOVEL CHITOSAN-BASED WOUND HEALING HYDROGEL FOR THE ENHANCEMENT OF LOCAL OXYGEN LEVELS AND FOR THE FACILITATION OF DERMAL TISSUE REPAIR [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron155567641759327

    APA Style (7th edition)

  • Fountas-Davis, Natalie. A NOVEL CHITOSAN-BASED WOUND HEALING HYDROGEL FOR THE ENHANCEMENT OF LOCAL OXYGEN LEVELS AND FOR THE FACILITATION OF DERMAL TISSUE REPAIR. 2019. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron155567641759327.

    MLA Style (8th edition)

  • Fountas-Davis, Natalie. "A NOVEL CHITOSAN-BASED WOUND HEALING HYDROGEL FOR THE ENHANCEMENT OF LOCAL OXYGEN LEVELS AND FOR THE FACILITATION OF DERMAL TISSUE REPAIR." Master's thesis, University of Akron, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron155567641759327

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.
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