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EXPLORATION OF THE MORPHOLOGY, CONNECTIVITY, AND FUNCTION OF MELANOPSIN GANGLION CELL OUTER RETINAL DENDRITES

Sondereker, Katelyn B
http://rave.ohiolink.edu/etdc/view?acc_num=akron1606144098442214

Abstract Details

2020, Doctor of Philosophy, University of Akron, Integrated Bioscience.
Melanopsin ganglion cells can respond to light independently of rods and cones due to expression of the photopigment melanopsin. There are currently six known types of melanopsin ganglion cells in the mouse retina (M1-M6). Early in development, a subset of M1 and displaced M1 (M1d) cells extend dendrites into the outer retina. These outer retinal dendrites (ORDs) run substantial distances through the inner nuclear layer (INL) and some extend into the outer plexiform layer (OPL) where they lie in close proximity to cone photoreceptor terminals. Here, the morphology, distribution, connectivity, and function of ORDs throughout development are explored. ORDs are morphologically distinct and asymmetrically distributed to the dorsal retina, suggesting that they may connect to m-opsin expressing cones. Interestingly, light deprivation significantly reduces the number of ORDs in the retina, indicating that light promotes the growth of ORDs into the outer retina during development. While M1d cells with ORDs do not express the transcription factor Brn3b, suggesting that they project to the superchiasmatic nucleus (SCN), M1 cells are Brn3b+ and presumably project to the olivary pretectal nucleus (OPN). As the studies presented here were conducted, an adaptable method for accurate and precise orientation of the mouse retina was also designed using an integrative approach to create an anatomical map of the mouse retina. Overall, the studies presented here further the understanding of the developing mouse retina and melanopsin ganglion cells while also providing a reliable anatomical map of the mouse retina that will continue to impact the validity of the many retinal studies to come.
Jordan Renna (Advisor)
Qin Liu (Committee Member)
Maureen Stabio (Committee Member)
Samuel Crish (Committee Member)
181 p.
Neurobiology; Neurosciences
melanopsin; ipRGC; retina; mouse; eye

Recommended Citations

Citations

  • Sondereker, K. B. (2020). EXPLORATION OF THE MORPHOLOGY, CONNECTIVITY, AND FUNCTION OF MELANOPSIN GANGLION CELL OUTER RETINAL DENDRITES [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1606144098442214

    APA Style (7th edition)

  • Sondereker, Katelyn. EXPLORATION OF THE MORPHOLOGY, CONNECTIVITY, AND FUNCTION OF MELANOPSIN GANGLION CELL OUTER RETINAL DENDRITES . 2020. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1606144098442214.

    MLA Style (8th edition)

  • Sondereker, Katelyn. "EXPLORATION OF THE MORPHOLOGY, CONNECTIVITY, AND FUNCTION OF MELANOPSIN GANGLION CELL OUTER RETINAL DENDRITES ." Doctoral dissertation, University of Akron, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1606144098442214

    Chicago Manual of Style (17th edition)

akron1606144098442214
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This open access ETD is published by University of Akron and OhioLINK.