Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


bgsu1162788653.pdf (1.03 MB)

ETD Abstract Container

Abstract Header

INFLUENCE OF A MIXTURE OF TWO POLYCHLORINATED BIPHENYLS (PCB 47/77) ON PRO-INFLAMMATORY CYTOKINES (IL-6, TNF-á) AND ASSOCIATIVE BEHAVIOR IN YOUNG SPRAGUE-DAWLEY RATS

Asbrock, Christina Marie
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162788653

Abstract Details

2006, Master of Science (MS), Bowling Green State University, Biological Sciences.
Polychlorinated biphenyls (PCB), are a group of 209 structurally related chemical compounds (congeners), that were once used in industrial applications, particularly as electrical insulating fluids and as heat exchange fluids, until concern regarding possible adverse effects on the environment and human health resulted in the cessation of production and an ultimate ban on manufacture in most countries. Upon the discovery of PCB in the environment, accounts of human exposure were investigated. PCB have been reported to cause a variety of health effects including immunologic, teratogenic, reproductive, carcinogenic, and neurologic. They are not only a potential health threat to adults, but also to developing fetuses and infants because they cross the human placenta and are found in human milk. In the present study, a simple mixture of PCB congeners, noncoplanar (PCB 47) and coplanar (PCB 77), were administered to young Sprague-Dawley rats by route of maternal dietary consumption (either 12.5 ppm or 25.0 ppm, w/w). Alterations in pup body, organ, and endocrine gland weight were determined on PND 15. Performance in conditioned odor preference (COP) tests and conditioned approach tests (CAT) was determined on PND 14 to examine the effects of PCB on the associative behavior of young rats. On PND 15, serum concentrations of circulating pro-inflammatory cytokines (IL-6, TNF-á) were determined using enzyme-linked immunosorbent assay (ELISA). Concentration of both IL-6 and TNF-á in serum were found to be positively correlated to administered PCB 47/77 concentration. Significant behavioral effects involving associative behavior and odor preference not observed in the present study. However, body weights at PND 15 were significantly depressed in animals exposed to PCB 47/77, and may be a physical symptom of sickness behavior that may have further been enhanced by the increased pro-inflammatory cytokine levels observed in the present study.
Lee Meserve (Advisor)
110 p.
PCB 47 77; pro-inflammatory cytokines IL-6 TNF; sprague-dawley; associative behavior

Recommended Citations

Citations

  • Asbrock, C. M. (2006). INFLUENCE OF A MIXTURE OF TWO POLYCHLORINATED BIPHENYLS (PCB 47/77) ON PRO-INFLAMMATORY CYTOKINES (IL-6, TNF-á) AND ASSOCIATIVE BEHAVIOR IN YOUNG SPRAGUE-DAWLEY RATS [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162788653

    APA Style (7th edition)

  • Asbrock, Christina. INFLUENCE OF A MIXTURE OF TWO POLYCHLORINATED BIPHENYLS (PCB 47/77) ON PRO-INFLAMMATORY CYTOKINES (IL-6, TNF-á) AND ASSOCIATIVE BEHAVIOR IN YOUNG SPRAGUE-DAWLEY RATS. 2006. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162788653.

    MLA Style (8th edition)

  • Asbrock, Christina. "INFLUENCE OF A MIXTURE OF TWO POLYCHLORINATED BIPHENYLS (PCB 47/77) ON PRO-INFLAMMATORY CYTOKINES (IL-6, TNF-á) AND ASSOCIATIVE BEHAVIOR IN YOUNG SPRAGUE-DAWLEY RATS." Master's thesis, Bowling Green State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162788653

    Chicago Manual of Style (17th edition)

bgsu1162788653
820
© 2006, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.