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Neurobehavioral and Neuroendocrine Assessment of Rats Perinatally Exposed to Polychlorinated Biphenyls: A Possible Model for Autism

Krishnan, Dena K
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1182708278

Abstract Details

2007, Master of Science (MS), Bowling Green State University, Biological Sciences.
Several studies have shown that perinatal exposure to xenobiotic mixtures such as polychlorinated biphenyls (PCBs) can cause physiological and behavioral disruption. These studies demonstrate that PCB-exposed rats are a possible model for understanding motor and social deficits in childhood developmental disorders like autism spectrum disorder (ASD). The mixture PCB 47/77 at 0 ppm, 12.5 ppm, or 25 ppm (w/w) of the diet was fed to pregnant Sprague-Dawley rats impacting offspring both indirectly and directly from GD 1 to PND 21. Motor functioning of offspring was tested at PND 14-16, 28-32, and 60-64 with measures of general motor activity and stereotypic repetitive behavior. Subsequently, t-maze learning acquisition and reversal was tested in males 25-29 days old and circulating levels of the hormone vasopressin were measured at 29 days of age by enzyme immunoassay. Numerous motoric impairments were found in PCB-exposed rats compared to controls including: 1) altered rates of activity, 2) significant delay in the formation of grooming chain syntax, 3) a longer latency in pup righting reflex, and 4) depressed ability to complete the hang and negative geotaxis tests at various stages of development. PCB-exposed rats showed a significant delay in t-maze learning aquisition and reversal in a dose dependent manner relative to controls. These consequences likely stem from neuroendocrine disruption despite no change in systemic circulating vasopressin concentration. The different results in animals given 12.5 ppm and 25 ppm PCB suggest use of this animal model to reveal a range of motoric disruption similar to the broad autistic phenotype.
Lee Meserve (Advisor)
73 p.
Biology, Neuroscience
PCB; Polychlorinated Biphenyls; environmental toxins; autism; vasopressin; grooming

Recommended Citations

Citations

  • Krishnan, D. K. (2007). Neurobehavioral and Neuroendocrine Assessment of Rats Perinatally Exposed to Polychlorinated Biphenyls: A Possible Model for Autism [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1182708278

    APA Style (7th edition)

  • Krishnan, Dena. Neurobehavioral and Neuroendocrine Assessment of Rats Perinatally Exposed to Polychlorinated Biphenyls: A Possible Model for Autism. 2007. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1182708278.

    MLA Style (8th edition)

  • Krishnan, Dena. "Neurobehavioral and Neuroendocrine Assessment of Rats Perinatally Exposed to Polychlorinated Biphenyls: A Possible Model for Autism." Master's thesis, Bowling Green State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1182708278

    Chicago Manual of Style (17th edition)

bgsu1182708278
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© 2007, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.