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Cannabidiol in Gummies. Determination of Effective Solvent-Based Extraction Methods.pdf (477.22 KB)
ETD Abstract Container
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Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods
Author Info
Clark, Abigail R
ORCID® Identifier
http://orcid.org/0000-0003-1340-156X
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954
Abstract Details
Year and Degree
2022, Master of Science (MS), Bowling Green State University, Forensic Science.
Abstract
Recent legislative changes in Ohio have led to crime laboratories making procedural changes away from qualitative analysis toward quantitative analysis of cannabinoid products. Several laboratories have developed methods for quantifying cannabinoids, but difficulties in sample preparation have impacted these methods. There are a multitude of cannabinoid products that exist, and food-based products predominantly consist of complex matrices. These matrices hinder the concentration of extracted cannabinoids, leading to an insufficient representation of those present. Four different methods of extraction expected to provide sufficient extraction of cannabidiol (CBD) were compared, specifically a QuEChERS method, an acetonitrile soak, a multi-solvent extraction utilized by the Virginia Department of Forensic Science (DFS), and a solvent comprised of methanol, formic acid, and water. These methods were tested on three flavors of “WYLD” CBD gummies: blackberry, huckleberry, and raspberry, as well as a control group using Annie’s Bunny Gummies containing no CBD. Based on percent recovery analysis, the manufacturer’s reported concentration of CBD contained within the gummies was significantly higher than the extracted values. However, no significant differences were found between the three gummy flavors, nor the three extraction methods that yielded results. There was statistically significant difference observed when comparing the control groups to the actual CBD gummies. Further research is required to determine reproducibility of results and optimization of the methods proposed.
Committee
Travis Worst, PhD. (Advisor)
Crystal Oechsle, PhD. (Committee Member)
Tanieka Motley, PhD. (Committee Member)
Pages
42 p.
Subject Headings
Analytical Chemistry
;
Chemistry
;
Pharmacology
Keywords
Cannabinoids
;
Cannabidiol
;
Extraction
;
Quantification
;
Solvent-Based
;
QuEChERS
;
LC/MS
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Refworks
EndNote
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Citations
Clark, A. R. (2022).
Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods
[Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954
APA Style (7th edition)
Clark, Abigail.
Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods.
2022. Bowling Green State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954.
MLA Style (8th edition)
Clark, Abigail. "Cannabidiol in Gummies: Determination of Effective Solvent-Based Extraction Methods." Master's thesis, Bowling Green State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1648754057865954
Chicago Manual of Style (17th edition)
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Document number:
bgsu1648754057865954
Download Count:
686
Copyright Info
© 2022, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.