Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


case1195243457.pdf (501.6 KB)

ETD Abstract Container

Abstract Header

MECHANISMS OF CALCIUM-MEDIATED ARRHYTHMOGENESIS IN HEART FAILURE

Hoeker, Gregory Scott
http://rave.ohiolink.edu/etdc/view?acc_num=case1195243457

Abstract Details

2008, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Abnormalities in calcium handling have been implicated in the mechanical and electrical dysfunction of heart failure (HF). While these abnormalities have been studied extensively in isolated myocytes, how they manifest in tissue is not well described. Furthermore, how abnormal calcium release within a single cell can trigger an arrhythmia is unclear. We hypothesize that in HF triggered arrhythmias are caused by spontaneous calcium release (SCR) occurring in clusters of cells, with SCR amplitude determining the arrhythmia threshold. We tested these hypotheses using optical mapping in canines with HF to study ratiometric calcium and calcium-voltage transients from the transmural surface of ventricular preparations. We found that in HF, calcium transients have reduced amplitude and increased duration. These calcium abnormalities are associated with nonreentrant arrhythmias, particularly during Β-adrenergic stimulation. The mechanism of these arrhythmias appears to be SCR-mediated triggered activity with the rate of calcium release determining whether the SCR reaches threshold.
Kenneth Laurita (Advisor)
Engineering, Biomedical
SCR; Calcium; calcium transients; HF; calcium release; SCR Events; amplitude

Recommended Citations

Citations

  • Hoeker, G. S. (2008). MECHANISMS OF CALCIUM-MEDIATED ARRHYTHMOGENESIS IN HEART FAILURE [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1195243457

    APA Style (7th edition)

  • Hoeker, Gregory. MECHANISMS OF CALCIUM-MEDIATED ARRHYTHMOGENESIS IN HEART FAILURE. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1195243457.

    MLA Style (8th edition)

  • Hoeker, Gregory. "MECHANISMS OF CALCIUM-MEDIATED ARRHYTHMOGENESIS IN HEART FAILURE." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1195243457

    Chicago Manual of Style (17th edition)

case1195243457
896
© 2007, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.