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ELECTROPORATION BY STRONG INTERNAL DEFIBRILLATION SHOCK IN INTACT STRUCTURALLY NORMAL AND CHRONICALLY INFARCTED RABBIT HEARTS

Kim, Seok Chan
http://rave.ohiolink.edu/etdc/view?acc_num=case1196122659

Abstract Details

2008, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
A strong internal defibrillation shock may damage the heart via disruption of cell membranes (electroporation). The spatial distribution and extent of electroporation were characterized in intact rabbit hearts with and without chronic (>4 weeks) left ventricular myocardial infarction (MI). An implantable defibrillator was inserted in the right ventricle, and one monophasic shock (+300-V, 8-ms) was delivered by a 150-μF capacitor clinical defibrillator. Electroporation was assessed by uptake of membrane-impermeant propidium iodide into ventricular myocardium through electropores. In control (n=2) and MI (n=2) groups without shock, PI uptake was minimal. In both control (n=5) and MI (n=5) groups with shock, electroporation mostly occurred near the shock electrode, distributed along the active region of the shock electrode. In the MI group with shock, shock-induced electroporation was significantly increased (p<0.05) in the surviving epicardial layer of the infarcted region. Between the control and MI groups, the overall extent of electroporation was similar.
Xin Yu (Advisor)
49 p.
Engineering, Biomedical
Electroporation; Defibrillation; Myocardial Infarction;

Recommended Citations

Citations

  • Kim, S. C. (2008). ELECTROPORATION BY STRONG INTERNAL DEFIBRILLATION SHOCK IN INTACT STRUCTURALLY NORMAL AND CHRONICALLY INFARCTED RABBIT HEARTS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1196122659

    APA Style (7th edition)

  • Kim, Seok. ELECTROPORATION BY STRONG INTERNAL DEFIBRILLATION SHOCK IN INTACT STRUCTURALLY NORMAL AND CHRONICALLY INFARCTED RABBIT HEARTS. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1196122659.

    MLA Style (8th edition)

  • Kim, Seok. "ELECTROPORATION BY STRONG INTERNAL DEFIBRILLATION SHOCK IN INTACT STRUCTURALLY NORMAL AND CHRONICALLY INFARCTED RABBIT HEARTS." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196122659

    Chicago Manual of Style (17th edition)

case1196122659
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© 2007, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.