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THE ROLE OF ALPHA 4 BETA 1 INTEGRIN (VLA-4) IN RECRUITMENT OF MYCOBACTERIUM TUBERCULOSIS-SPECIFIC TH1-LIKE RECALL RESPONSES TO THE HUMAN LUNG

Walrath, Jessica R.
http://rave.ohiolink.edu/etdc/view?acc_num=case1196182534

Abstract Details

2008, Master of Sciences, Case Western Reserve University, Pathology.
Tuberculosis remains a major international health threat. Although BCG vaccination does not clearly protect against pulmonary tuberculosis, Mycobacterium tuberculosisexposed individuals are relatively protected against subsequent re-infection. We have utilized bronchoscopic antigen challenge with PPD to model immune responses of infected individuals following re-exposure. Currently, we assessed the role of homing molecules in recruitment of M. tuberculosis-specific recall responses to the human lung. Intracellular staining for IFN&gamma was performed, as was surface staining for &alpha 4&beta 1 and &alpha 4&beta 7 integrins and CLA. Baseline bronchoalveolar lavage (BAL) is enriched for &alpha 4&beta 1-expressing CD4+ T-cells. This skewing continues following PPD-induced lymphocyte recruitment, and is even more pronounced for M. tuberculosis-specific CD4+ T-cells. Expression of &alpha 4&beta 1 integrin therefore appears to mediate optimal localization of recall responses to the lung. Comparison with vaccinated subjects may clarify whether intradermal BCG is as effective as natural infection in inducing recall responses that can be localized to the lung.
Richard Silver (Advisor)
55 p.
Health Sciences, Pathology
&; alpha 4&; beta 1; VLA-4; Mycobacterium tuberculosis; BCG; homing

Recommended Citations

Citations

  • Walrath, J. R. (2008). THE ROLE OF ALPHA 4 BETA 1 INTEGRIN (VLA-4) IN RECRUITMENT OF MYCOBACTERIUM TUBERCULOSIS-SPECIFIC TH1-LIKE RECALL RESPONSES TO THE HUMAN LUNG [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1196182534

    APA Style (7th edition)

  • Walrath, Jessica. THE ROLE OF ALPHA 4 BETA 1 INTEGRIN (VLA-4) IN RECRUITMENT OF MYCOBACTERIUM TUBERCULOSIS-SPECIFIC TH1-LIKE RECALL RESPONSES TO THE HUMAN LUNG. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1196182534.

    MLA Style (8th edition)

  • Walrath, Jessica. "THE ROLE OF ALPHA 4 BETA 1 INTEGRIN (VLA-4) IN RECRUITMENT OF MYCOBACTERIUM TUBERCULOSIS-SPECIFIC TH1-LIKE RECALL RESPONSES TO THE HUMAN LUNG." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196182534

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.