Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


case1196266590.pdf (1.4 MB)

ETD Abstract Container

Abstract Header

AN INTEGRATED INFORMATICS INFRASTRUCTURE FOR PRE-CLINICAL RESEARCH-IT SUPPORT

Szymanski, Jacek
http://rave.ohiolink.edu/etdc/view?acc_num=case1196266590

Abstract Details

2008, Doctor of Philosophy, Case Western Reserve University, Computing and Information Science.
Modern scientific research is inherently multi-leveled and multidisciplinary. High-throughput scanners and powerful, new generations of equipment operating at core facilities are essential tools for advancing research in disciplines such as bioscience and medicine. They produce large and complex data that must be safely archived and at the same time easily accessible. Together with administrative management tasks, core facilities face a crushing burden in research-IT support. This dissertation introduces a Multi-modality Multi-resource Information Integration (MIMI) system that combines scientific and administrative support in a seamlessly integrated environment. MIMI captures a complete set of raw information about people, projects, resources, materials, accounting, scheduling, and scientific data. It replaces the existing piece-meal and disintegrated approach to research-IT support by a single comprehensive package. No other system in the market today provides such a complete set of features to meet the informatics infrastructure challenge. MIMI is created from object-oriented data models that represent the flow of information at core facilities and capture a high-level view of their daily operations. MIMI contributes to the design and implementation of interacting workflows that account for the scientific and administrative logics of a core facility. Implemented in the open source content-management system Plone, MIMI has been developed in a style that translates to certain practices of the extreme programming paradigm. MIMI employs the latest techniques in web-based systems such as DHTML, CSS, and AJAX. Additional features include semi-automated dataflow, personalized experimental workflow management, and a dynamic programming approach for optimizing the scheduling of multi-step studies. MIMI has been deployed at the Case Center for Imaging Research and is being deployed at the Case Center for Proteomics. Cost-benefit analysis shows that substantial financial savings can be accrued long term. Given the magnitude of research performed at core facilities, MIMI not only indirectly impacts research by reducing management overhead, it may also directly impact bioscience and medicine by enabling a more system-oriented approach, now that a greater variety of relevant data and information becomes readily available at the fingertips of researchers.
Guo-Qiang Zhang (Advisor)
159 p.
MIMI; Scienti¿¿¿¿¿¿c; Core facilities; CCIR

Recommended Citations

Citations

  • Szymanski, J. (2008). AN INTEGRATED INFORMATICS INFRASTRUCTURE FOR PRE-CLINICAL RESEARCH-IT SUPPORT [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1196266590

    APA Style (7th edition)

  • Szymanski, Jacek. AN INTEGRATED INFORMATICS INFRASTRUCTURE FOR PRE-CLINICAL RESEARCH-IT SUPPORT. 2008. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1196266590.

    MLA Style (8th edition)

  • Szymanski, Jacek. "AN INTEGRATED INFORMATICS INFRASTRUCTURE FOR PRE-CLINICAL RESEARCH-IT SUPPORT." Doctoral dissertation, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196266590

    Chicago Manual of Style (17th edition)

case1196266590
1,577
© 2007, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.