Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


case1207614029.pdf (321.39 KB)

ETD Abstract Container

Abstract Header

The Effectiveness and Safety of Mycophenolate Mofetil in Lupus Nephritis

Elyan, Mazen
http://rave.ohiolink.edu/etdc/view?acc_num=case1207614029

Abstract Details

2008, Master of Sciences, Case Western Reserve University, Clinical Research.
Objective: To evaluate the effectiveness and safety of Mycophenolate Mofetil (MMF) in lupus nephritis (LN). Methods: A retrospective study of 25 LN patients consecutively treated with MMF. The primary outcome was complete renal remission (CR): urine protein/creatinine ≤0.5 g/g, inactive urine sediment and stable serum creatinine within <15% above baseline. Results: 57% achieved CR (Median time 8.5 months). CR was correlated with MMF dose and LN duration. Of 13 patients who had LN for <12 months and took ≥2 grams/day of MMF, 11 achieved CR, versus 1 of 8 patients who did not meet both criteria (p=0.002). 87% of patients maintained remission (Median follow-up: 20 months) while taking MMF. Most adverse events were transient and did not require therapy changes. Conclusions: MMF is effective and safe for induction and/or maintenance of remission of LN. Early treatment with ≥2 grams/day is essential for optimal outcome. CR may take >6 months.
Barbara Cromer, MD (Committee Chair)
Stanley Ballou, MD (Committee Member)
Steven Lewis, MS, MBA (Committee Member)
Biomedical Research
Mycophenolate Mofetil; lupus nephritis

Recommended Citations

Citations

  • Elyan, M. (2008). The Effectiveness and Safety of Mycophenolate Mofetil in Lupus Nephritis [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1207614029

    APA Style (7th edition)

  • Elyan, Mazen. The Effectiveness and Safety of Mycophenolate Mofetil in Lupus Nephritis. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1207614029.

    MLA Style (8th edition)

  • Elyan, Mazen. "The Effectiveness and Safety of Mycophenolate Mofetil in Lupus Nephritis." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207614029

    Chicago Manual of Style (17th edition)

case1207614029
2,410
© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.