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Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis

Fang, Yu-Hua
http://rave.ohiolink.edu/etdc/view?acc_num=case1238635584

Abstract Details

2009, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
In the recent years molecular imaging has become an important tool in biomedical research. To quantify physiology from image data, compartment modeling has been shown to be useful by analyzing the pharmacokinetics from molecular images. However, some challenges still exist and limit the application of compartment modeling in a routine basis. Methods to resolve some of the existing challenges are proposed and validated in this thesis. First, non-invasive methods are developed to measure the input functions required in compartment modeling and parameter estimation for positron-emission tomography (PET) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) studies. Methods for image-derived input functions are developed and validated against the reference input functions. Second, a software environment is established to integrate functions that handle image analysis and modeling analysis based on COmpartment Model Kinetic Analysis Tool (COMKAT). Methods to enhance speed and interface for COMKAT have been implemented as described in this thesis. With the methods and software developed in this thesis, researchers can quantify in vivo pharmacokinetics with molecular imaging methods to measure the physiology and metabolism non-invasively in a routine basis.
Raymond Muzic, PhD (Advisor)
Xin Yu, PhD (Committee Chair)
Gerald Saidel, PhD (Committee Member)
Peter Faulhaber, MD (Committee Member)
196 p.
Biomedical Research; Engineering
Kinetic modeling; compartment modeling; molecular imaging; PET; MRI; quantification

Recommended Citations

Citations

  • Fang, Y.-H. (2009). Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1238635584

    APA Style (7th edition)

  • Fang, Yu-Hua. Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis. 2009. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1238635584.

    MLA Style (8th edition)

  • Fang, Yu-Hua. "Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis." Doctoral dissertation, Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1238635584

    Chicago Manual of Style (17th edition)

case1238635584
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© 2009, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.