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The Longitudinal Analysis of Silicone Hydrogel Contact Lens Study

Szczotka-Flynn, Loretta B.
http://rave.ohiolink.edu/etdc/view?acc_num=case1257182345

Abstract Details

2010, Doctor of Philosophy, Case Western Reserve University, Epidemiology and Biostatistics.
The Longitudinal Analysis of Silicone Hydrogel Contact Lens Study (LASH Study) was a prospective cohort study of silicone hydrogel contact lens wearers who slept in their lenses for up to 29 consecutive nights (30 days) of continuous wear, with monthly disposal. Two hundred five healthy myopic or hyperopic patients with minimal or no astigmatism and no contraindications to continuous wear lens use were followed for 1 year. The primary outcome measure was the time to development of a corneal infiltrative event as defined by slit lamp findings and patient symptoms. Survival analysis techniques were used to assess key predictor variables as potential risk factors. The main exposure of interest was corneal staining followed by bacterial contamination of study lenses. Bacterial contamination was found to be common with continuous wear use of silicone hydrogel lenses and the primary risk factor for development of a corneal infiltrative event. Corneal staining was not associated with the development of a corneal infiltrative event. Alteration of the protective mucus layer of the tear film as evidenced by mucin balls trapped behind the lens was found to play a protective role. This information will be helpful for practitioners as they select and monitor patients for this mode of lens wear, and for manufacturers as they design future generations of contact lenses.
Alfred Rimm, PhD (Committee Chair)
Sara Debanne, PhD (Committee Member)
Ajay Sethi, PhD (Committee Member)
Jonathan Lass, MD (Committee Member)
Desmond Fonn, MOptom (Committee Member)
Epidemiology; Health Care; Microbiology; Ophthalmology
contact lens; corneal infiltrative events; contact lens microbial contamination

Recommended Citations

Citations

  • Szczotka-Flynn, L. B. (2010). The Longitudinal Analysis of Silicone Hydrogel Contact Lens Study [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1257182345

    APA Style (7th edition)

  • Szczotka-Flynn, Loretta. The Longitudinal Analysis of Silicone Hydrogel Contact Lens Study. 2010. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1257182345.

    MLA Style (8th edition)

  • Szczotka-Flynn, Loretta. "The Longitudinal Analysis of Silicone Hydrogel Contact Lens Study." Doctoral dissertation, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1257182345

    Chicago Manual of Style (17th edition)

case1257182345
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© 2009, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.