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Role of Mal/TIRAP in TLR2- and TLR4-, but not TLR5-Induced Corneal Inflammation

Williams, Susan R.
http://rave.ohiolink.edu/etdc/view?acc_num=case1259983828

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Pathology.
Neutrophil recruitment to the cornea and corneal haze produced by cellular infiltration and tissue damage are characteristic features of infectious bacterial keratitis or sterile keratitis due to bacterial products. In this context, these responses are mediated by TLRs, particularly TLR2, TLR4 and TLR5. Understanding the regulation of the activity of these receptors in the cornea may be important for dissecting host responses to pathogens and designing interventions for therapeutic targets. The TIRAP adaptor protein was examined as a regulator of these responses in mouse models of Pam3CysK4/TLR2-, LPS/TLR4- and flagellin/TLR5- induced sterile keratitis; we demonstrated that TIRAP participates in TLR2- and TLR4- induced neutrophil recruitment and stromal haze but did not influence TLR5-induced responses. Moreover, TIRAP-independent TLR4 responses were not apparent. Based on these findings, we hypothesize that TIRAP mediates TLR2 and TLR4 induced keratitis responses upon bacterial product recognition.
Eric Pearlman, PhD (Advisor)
TIRAP; CORNEAL; Keratitis; Cornea; TLR; TLR4; TLR2-AND

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Citations

  • Williams, S. R. (2010). Role of Mal/TIRAP in TLR2- and TLR4-, but not TLR5-Induced Corneal Inflammation [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1259983828

    APA Style (7th edition)

  • Williams, Susan. Role of Mal/TIRAP in TLR2- and TLR4-, but not TLR5-Induced Corneal Inflammation. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1259983828.

    MLA Style (8th edition)

  • Williams, Susan. "Role of Mal/TIRAP in TLR2- and TLR4-, but not TLR5-Induced Corneal Inflammation." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1259983828

    Chicago Manual of Style (17th edition)

case1259983828
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© 2009, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.