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DESIGN AND FABRICATION OF A MICROFLUIDIC ELECTROCHEMICAL PH-STAT

Stanton, John W.
http://rave.ohiolink.edu/etdc/view?acc_num=case1270498159

Abstract Details

2010, Master of Sciences (Engineering), Case Western Reserve University, EECS - Electrical Engineering.
Conventional pH-stats use titration to add acid or base solution to control sample pH. This technique is impractical for small volume samples because fluidic addition leads to dilution. The goal of this work is to produce a microfluidic electrochemical pH-stat, which utilizes water electrolysis for hydrogen/hydroxyl ion generation. This technique does not induce volume change and can be precisely controlled and measured to determine reaction rates. The device consists of a PDMS-based microchannel that is sandwiched between two glass substrates. The glass substrates support microfabricated electrodes for current injection and pH sensing. Fabrication of the pH-stat utilizes a novel vacuum-assisted micromolding process capable of producing microfluidic channels while maintaining substrate and electrode surface integrity. The pH-stat analyzes two microliters of fluid, uses capillary flow for fluid transport, and ion diffusion as the mixing mechanism. Preliminary evaluation with a sample containing pH-dye shows successful fluid transport, pH modification, and ion diffusion.
Christian Zorman (Advisor)
Miklos Gratzl (Committee Member)
Frank Merat (Committee Member)
Electrical Engineering
PDMS; electrochemical pH-stat; microfabrication; glass-PDMS-glass;

Recommended Citations

Citations

  • Stanton, J. W. (2010). DESIGN AND FABRICATION OF A MICROFLUIDIC ELECTROCHEMICAL PH-STAT [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1270498159

    APA Style (7th edition)

  • Stanton, John. DESIGN AND FABRICATION OF A MICROFLUIDIC ELECTROCHEMICAL PH-STAT. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1270498159.

    MLA Style (8th edition)

  • Stanton, John. "DESIGN AND FABRICATION OF A MICROFLUIDIC ELECTROCHEMICAL PH-STAT." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270498159

    Chicago Manual of Style (17th edition)

case1270498159
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.