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Implementing and Evaluating MQLAIP: A Metabolism Query Language

Patel, Gajendra
http://rave.ohiolink.edu/etdc/view?acc_num=case1289591644

Abstract Details

2010, Master of Sciences, Case Western Reserve University, EECS - Computer and Information Sciences.
Metabolism is a representation of the biochemical principles that govern the production, consumption, degradation and biosynthesis of metabolites in living cells. Organisms respond to changes in their physiological conditions or environmental perturbations (i.e., constraints) via cooperative implementation of such principles. Querying inner working principles of metabolism under different constraints provides invaluable insights for both researchers and educators. This thesis describes the implementation and evaluation of a type of a metabolism query language (MQL) for exploring activated/inactivated paths under specified metabolic conditions, referred to as MQLAIP queries. The query results of MQLAIP are enriched with both textual and visual representations; and its query processing is designed based on underlying metabolic biochemistry principles.MQL system, implemented within PathCase-MAW framework,is able to explain its reasoning for annotating reactions as active or inactive, in the selected sub-network using metabolic biochemistry.
Dr. Gultekin Özsoyoğlu (Advisor)
Dr. Jing Li (Committee Member)
Dr. Mehmet Koyuturk (Committee Member)
Dr. Z. Meral Özsoyoğlu (Committee Member)
88 p.
Artificial Intelligence; Biochemistry; Bioinformatics; Computer Science; Engineering
graphical; metabolic; network; query language; query processor; pathway; Metabolism; graph

Recommended Citations

Citations

  • Patel, G. (2010). Implementing and Evaluating MQLAIP: A Metabolism Query Language [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1289591644

    APA Style (7th edition)

  • Patel, Gajendra. Implementing and Evaluating MQLAIP: A Metabolism Query Language. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1289591644.

    MLA Style (8th edition)

  • Patel, Gajendra. "Implementing and Evaluating MQLAIP: A Metabolism Query Language." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1289591644

    Chicago Manual of Style (17th edition)

case1289591644
565
© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.
Release 3.2.12