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A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide

Khasnis, Atul Ashok

Abstract Details

2011, Master of Sciences, Case Western Reserve University, Clinical Research.
OBJECTIVE: To assess the cost-effectiveness of weekly compared to monthly white blood count (WBC) monitoring in patients with severe granulomatosis with polyangiitis (GPA) receiving oral cyclophosphamide (CYC). METHODS: The two CBC monitoring approaches for surveillance of leukopenia and its consequences were compared using a decision analysis model. The prevalence of leukopenia, infections, and outcomes were obtained from an existing registry and published reports. Costs were in dollars (2010) and effectiveness as quality-adjusted life-years (QALYs) gained. RESULTS: The expected utility of weekly CBC monitoring of these patients for leukopenia is 18.74 QALYs versus 18.52 QALYs with monthly CBC. The expected gain is 0.22 QALYs and incurs $489 lower cost per patient. The weekly CBC strategy mostly dominated the monthly CBC strategy. CONCLUSION: Weekly CBC monitoring is cost-effective for prevention of severe leukopenia and severe infections in patients on CYC for severe GPA.
Thomas Love, PhD (Committee Chair)
Richard Wilson, MD, MS (Committee Member)
Carol Langford, MD, MHS (Advisor)
Donald Anthony, MD, PhD (Committee Member)
109 p.

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Citations

  • Khasnis, A. A. (2011). A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641

    APA Style (7th edition)

  • Khasnis, Atul. A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide. 2011. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641.

    MLA Style (8th edition)

  • Khasnis, Atul. "A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide." Master's thesis, Case Western Reserve University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641

    Chicago Manual of Style (17th edition)