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Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies

Evans, Sarah Frances
http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902

Abstract Details

2012, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
The periosteum serves as a stabilizing boundary membrane to the bone it envelopes and contains mechanosensitive progenitor cells capable of promoting new bone formation. Knowledge of the structure-function relationships underlying the dynamic mechanical and regenerative properties of the periosteum is lacking. The following work investigates the structure-function relationships present in periosteum at both the tissue and cellular level. At the tissue level, periosteum permeability is characterized and found to exhibit barrier membrane properties. Subsequently, cell scale studies investigate the molecular characteristics of periosteum cells responsible for enabling tissue-level barrier membrane properties. Lastly, a biomimetic membrane system for investigating cell-cell adhesions of periosteum cells is developed. Culture of periosteum cells on the model membrane system results in signs of early osteogenic lineage commitment. Characterization of structure-function relationships in periosteum across multiple lengths scales provides knowledge valuable for the development of predictive computational models and tissue engineered periosteal replacement membranes.
Melissa Knothe Tate, PhD (Committee Chair)
Gerals Saidel, PhD (Committee Member)
Joseph Mansour, PhD (Committee Member)
104 p.
Biomechanics; Biomedical Engineering; Biomedical Research
periosteum; mechanobiology; tissue level mechanical properties; perioisteum derived cells; permeability;

Recommended Citations

Citations

  • Evans, S. F. (2012). Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902

    APA Style (7th edition)

  • Evans, Sarah. Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies. 2012. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902.

    MLA Style (8th edition)

  • Evans, Sarah. "Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies." Master's thesis, Case Western Reserve University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902

    Chicago Manual of Style (17th edition)

case1331646902
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© 2012, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.