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Controlled Flow Cavitation Technology For Use In Pharmaceutical Processing Applications And Its Commercialization Plan

Chen, Chien-Chih
http://rave.ohiolink.edu/etdc/view?acc_num=case1339184669

Abstract Details

2012, Master of Sciences, Case Western Reserve University, Chemistry.
Many new drugs fail to pass clinical trials every year because of poor bioavailability. More than 40% of those New Chemical Entities fail to reach commercialization due to poor solubility. Nanotechnology, which can increase the active surface area, often is employed to improve the solubility of drugs. However, existing technologies using top-down approaches such as grinding, milling, and homogenization have issues of inconsistent particle size distribution, batch contamination, scalability, and high maintenance costs. There is a need to develop a bottom-up nanotechnology approach. This thesis focuses on the development and commercialization of GenSyn’s particle engineering capabilities using in-house Controlled Flow Cavitation (CFC¿¿¿¿¿¿¿) Technology for its use in pharmaceutical processing. Based on the initial results, the commercialization of GenSyn’s particle engineering capabilities is considered feasible.
Irene Lee, PhD (Committee Chair)

Recommended Citations

Citations

  • Chen, C.-C. (2012). Controlled Flow Cavitation Technology For Use In Pharmaceutical Processing Applications And Its Commercialization Plan [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1339184669

    APA Style (7th edition)

  • Chen, Chien-Chih. Controlled Flow Cavitation Technology For Use In Pharmaceutical Processing Applications And Its Commercialization Plan. 2012. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1339184669.

    MLA Style (8th edition)

  • Chen, Chien-Chih. "Controlled Flow Cavitation Technology For Use In Pharmaceutical Processing Applications And Its Commercialization Plan." Master's thesis, Case Western Reserve University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339184669

    Chicago Manual of Style (17th edition)

case1339184669
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© 2012, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.