Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


dissertation v6 final.pdf (8.53 MB)

ETD Abstract Container

Abstract Header

Affinity-based Delivery and Reloading of Doxorubicin For Treatment of Glioblastoma Multiforme

Fu, Andrew Song
http://rave.ohiolink.edu/etdc/view?acc_num=case1372345676

Abstract Details

2013, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
A reloadable drug delivery implant would allow for customizable chemotherapy tailored to the tumor progression of the individual patient. We report, for the first time, a polymer implant engineered to not only provide controlled delivery of an anticancer drug doxorubicin, but also to serve as a sponge that can absorb additional doses if needed. Numerous analytical methods were employed to characterize the affinity between doxorubicin and our affinity-based polymers consisting of cyclodextrin. Drug release and reloading were controlled by specific and reversible interactions between doxorubicin and cyclodextrin. Polymer synthesis conditions were optimized in vitro to ensure sufficient and fast-acting reloading in vivo. When implanted in a human brain tumor xenograft model in nude mice, our reloadable drug delivery platform enhanced the efficacy of localized chemotherapy. These results reflect the effectiveness of reloadable affinity-based polymers for providing local, flexible, and long-term treatment for cancer.
Horst von Recum (Committee Chair)
175 p.
Biomedical Engineering
affinity-based drug delivery; glioblastoma multiforme,

Recommended Citations

Citations

  • Fu, A. S. (2013). Affinity-based Delivery and Reloading of Doxorubicin For Treatment of Glioblastoma Multiforme [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1372345676

    APA Style (7th edition)

  • Fu, Andrew. Affinity-based Delivery and Reloading of Doxorubicin For Treatment of Glioblastoma Multiforme. 2013. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1372345676.

    MLA Style (8th edition)

  • Fu, Andrew. "Affinity-based Delivery and Reloading of Doxorubicin For Treatment of Glioblastoma Multiforme." Doctoral dissertation, Case Western Reserve University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1372345676

    Chicago Manual of Style (17th edition)

case1372345676
1,321
© 2013, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.