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Sabina Kumar's MS Thesis.pdf (1.26 MB)

ETD Abstract Container

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Quantative Evaluation of Myoglobin and Hemoglobin Oxygenation during Contraction using Near-Infrared Spectroscopy

Kumar, Sabina
http://rave.ohiolink.edu/etdc/view?acc_num=case1431681312

Abstract Details

2015, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
117 million people in the United States today suffers from a chronic disease associated with an insufficient oxygen delivery to muscle. Clinicians need a fast, easy, non-invasive way to measure oxygen saturation. Near-Infrared Spectroscopy (NIRS) is a non-invasive procedure whose signal reflects tissue oxygenation. We hypothesized however that near-infrared spectroscopy (NIRS) measures of hemoglobin and/or myoglobin 02 saturation do not reflect the venous oxygen saturation because of the Hb and Mb contributions to the NIRS signal. A computational model previously developed to describe the dynamic and spatial changes of O2 concentration in blood and tissue domains of contracting skeletal muscle was modified to quantify Hb and Mb contributions to the NIRS signal. In addition, the effect of blood flow kinetics in a normal and disease state with corresponding NIRS signals were also analyzed.
Nicola Lai, Ph.D (Committee Chair)
Saidel Gerald, Ph.D (Advisor)
Colin Drummond, Ph.D (Committee Member)
24 p.
Biomedical Engineering
Near-Infrared Spectroscopy, Venous Oxygenation, Oxygen Delivery

Recommended Citations

Citations

  • Kumar, S. (2015). Quantative Evaluation of Myoglobin and Hemoglobin Oxygenation during Contraction using Near-Infrared Spectroscopy [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1431681312

    APA Style (7th edition)

  • Kumar, Sabina. Quantative Evaluation of Myoglobin and Hemoglobin Oxygenation during Contraction using Near-Infrared Spectroscopy. 2015. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1431681312.

    MLA Style (8th edition)

  • Kumar, Sabina. "Quantative Evaluation of Myoglobin and Hemoglobin Oxygenation during Contraction using Near-Infrared Spectroscopy." Master's thesis, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1431681312

    Chicago Manual of Style (17th edition)

case1431681312
460
© 2015, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.